Concomitant use of 18F-FDG PET-CT SUVmax is useful in the assessment of Ki67 labeling index in core-needle biopsy specimens of breast cancer
| العنوان: | Concomitant use of 18F-FDG PET-CT SUVmax is useful in the assessment of Ki67 labeling index in core-needle biopsy specimens of breast cancer |
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| المؤلفون: | Takaaki Oba, Tokiko Ito, Ken-ichi Ito, Fumiyoshi Takayama, Kazuma Maeno, Tsuyoshi Uehara, Mayu Ono, Toshiharu Kanai, Hiroki Nakajima |
| المصدر: | Gland Surg |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Predictive marker, medicine.diagnostic_test, business.industry, Concordance, Standardized uptake value, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Positron emission tomography, 030220 oncology & carcinogenesis, Concomitant, Biopsy, medicine, Immunohistochemistry, Original Article, Surgery, business, Nuclear medicine |
| الوصف: | BACKGROUND: Ki67 is a recognized proliferative and predictive marker in invasive breast cancer. However, results of Ki67 evaluation are affected by the method employed for sample fixation or biopsy, as well as by intratumor heterogeneity. Here, we aimed to compare the Ki67 labeling index (Ki67LI) between core-needle biopsy specimens (CNBSs) and surgically resected specimens (SRSs) of invasive breast cancer, and verify whether the discordance in Ki67LI can be reduced by analyzing the maximum standardized uptake value (SUVmax) obtained from pretreatment whole-body positron emission tomography/computed tomography (PET/CT) in combination with Ki67LI. METHODS: Tumor tissues were obtained from 118 patients with invasive breast cancer. Ki67LI was evaluated in CNBSs and SRSs by immunohistochemistry. First, we directly compared Ki67LI between CNBS and SRS, “allowing a tolerance margin of 5%.” We divided the Ki67LI values into three groups (Low: 0≤ Ki67LI ≤10, Intermediate: 10< Ki67LI |
| تدمد: | 2227-8575 2227-684X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c18f7e8fc919523825b0e1083bc8a6 https://doi.org/10.21037/gs-20-485 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....98c18f7e8fc919523825b0e1083bc8a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22278575 2227684X |
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