Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases
| العنوان: | Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases |
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| المؤلفون: | Brian P Eyden, Deepak Pandit, Saumitra S Banerjee |
| المصدر: | Histopathology. 47:402-409 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Lung Neoplasms, Skin Neoplasms, Histology, Nose Neoplasms, Cell morphology, Neuroendocrine differentiation, Pathology and Forensic Medicine, Microscopy, Electron, Transmission, Biomarkers, Tumor, medicine, Humans, Melanoma, neoplasms, Aged, biology, Mucosal melanoma, Chromogranin A, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, HMB-45, Lymphatic Metastasis, Cutaneous melanoma, biology.protein, Synaptophysin, Female |
| الوصف: | Aim : To document the clinical, histological, immunohistochemical and ultrastructural features of three malignant melanomas showing neuroendocrine differentiation. Methods and results : Three patients, two with primary cutaneous melanoma and one with nasal mucosal melanoma, subsequently developing or simultaneously presenting with metastatic malignant melanoma, were studied by conventional histological technique, immunohistochemistry of formalin-fixed paraffin-wax embedded tissues, and electron microscopy of epoxy-resin-embedded tumour tissue. Tumours showed either small cell or conventional malignant melanoma cell morphology. One of the three primary melanocytic lesions (the nasal melanoma) exhibited neuroendocrine differentiation immunohistochemically. All three metastatic malignant melanomas showed, in varying combinations, immunohistochemical and ultrastructural evidence for neuroendocrine differentiation: they were positive for the melanocytic markers, S100 protein, HMB-45, Melan-A and tyrosinase, and the neuroendocrine markers chromogranin, synaptophysin and neurofilament protein. Ultrastructural study in two of the metastases revealed neuroendocrine granules but no lattice-bearing melanosomes. Conclusions : The cases described are the most comprehensively investigated malignant melanomas showing neuroendocrine differentiation to date, and the first to document neuroendocrine differentiation ultrastructurally in these tumours. Malignant melanoma with neuroendocrine differentiation therefore needs to be recognized among the other, better known variants of malignant melanoma. |
| تدمد: | 1365-2559 0309-0167 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999911b8d06c769a4a5c4411f42af2a2 https://doi.org/10.1111/j.1365-2559.2005.02240.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....999911b8d06c769a4a5c4411f42af2a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652559 03090167 |
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