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A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

التفاصيل البيبلوغرافية
العنوان: A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
المؤلفون: Paulina Kaplonek, Ling Yao, Katrin Reppe, Franziska Voß, Thomas Kohler, Friederike Ebner, Alexander Schäfer, Ulrike Blohm, Patricia Priegue, Maria Bräutigam, Claney L. Pereira, Sharavathi G. Parameswarappa, Madhu Emmadi, Petra Ménová, Martin Witzenrath, Sven Hammerschmidt, Susanne Hartmann, Leif E. Sander, Peter H. Seeberger
المصدر: Vaccine
bioRxiv
بيانات النشر: Elsevier BV, 2022.
سنة النشر: 2022
مصطلحات موضوعية: General Veterinary, General Immunology and Microbiology, Swine, Public Health, Environmental and Occupational Health, Serogroup, Antibodies, Bacterial, Pneumococcal Infections, Pneumococcal Vaccines, Mice, Streptococcus pneumoniae, Infectious Diseases, Bacterial Proteins, Animals, Molecular Medicine, Glycoconjugates
الوصف: Streptococcus pneumoniae (S. pneumoniae) infections are the leading cause of child mortality globally. Current vaccines fail to induce a protective immune response towards a conserved part of the pathogen, resulting in new serotypes causing disease. Therefore, new vaccine strategies are urgently needed. Described is a two-pronged approach combining S. pneumoniae proteins, pneumolysin (Ply) and pneumococcal surface protein A (PspA), with a precisely defined synthetic oligosaccharide, whereby the carrier protein acts as a serotype-independent antigen to provide additional protection. Proof of concept in mice and swine models revealed that the conjugates inhibited colonization of the nasopharynx, decreased the bacterial load and reduced disease severity in the bacteria challenge model. Immunization of piglets provided the first evidence for the immunogenicity and protective potential of synthetic glycoconjugate vaccine in a large animal model. A combination of synthetic oligosaccharides with proteins from the target pathogen opens the path to create broadly cross-protective (“universal”) pneumococcal vaccines.
وصف الملف: application/pdf
تدمد: 0264-410X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c7b2c9ac495244c7d58e1509e1a374
https://doi.org/10.1016/j.vaccine.2021.12.068
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....99c7b2c9ac495244c7d58e1509e1a374
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0264410X