The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
| العنوان: | The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach |
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| المؤلفون: | Taimei Miyagawa, Shunichi Ishida, Niranchan Paskaranandavadivel, Thomas L. Abell, Leo K. Cheng, Timothy R. Angeli, Tim Hsu Han Wang, Peng Du, Gianrico Farrugia, Yohsuke Imai, Gregory O'Grady, Armen A. Gharibans |
| المصدر: | Physiological Reports Physiological Reports, Vol 8, Iss 24, Pp n/a-n/a (2021) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Aging, medicine.medical_specialty, Physiology, Normal aging, 030204 cardiovascular system & hematology, slow wave velocity, Nerve conduction velocity, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Human stomach, interstitial cells of Cajal (ICC), Physiology (medical), Internal medicine, medicine, QP1-981, Humans, Computer Simulation, human, Gastroparesis, Aged, Original Research, Gastric emptying, business.industry, Stomach, computational simulation, Middle Aged, Interstitial Cells of Cajal, medicine.disease, Interstitial cell of Cajal, Amplitude, medicine.anatomical_structure, Gastric Emptying, Cardiology, symbols, Peristalsis, business, 030217 neurology & neurosurgery |
| الوصف: | Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined. This study correlated human gastric slow wave velocity with ICC loss and aging. High‐resolution gastric slow wave mapping data were screened from a database of 42 patients with severe gastric dysfunction (n = 20) and controls (n = 22). Correlations were performed between corpus slow wave conduction parameters (frequency, velocity, and amplitude) and corpus ICC counts in patients, and with age in controls. Physiological parameters were further integrated into computational models of gastric mixing. Patients: ICC count demonstrated a negative correlation with slow wave velocity in the corpus (i.e., higher velocities with reduced ICC; r 2 = .55; p = .03). ICC count did not correlate with extracellular slow wave amplitude (p = .12) or frequency (p = .84). Aging: Age was positively correlated with slow wave velocity in the corpus (range: 25–74 years; r 2 = .32; p = .02). Age did not correlate with extracellular slow wave amplitude (p = .40) or frequency (p = .34). Computational simulations demonstrated that the gastric emptying rate would increase at higher slow wave velocities. ICC loss and aging are associated with a higher slow wave velocity. The reason for these relationships is unexplained and merit further investigation. Increased slow wave velocity may modulate gastric emptying higher, although in gastroparesis other pathological factors must dominate to prevent emptying. Loss of interstitial cells of Cajal and aging is associated with a higher gastric slow wave velocity. This study used human data for correlation and computational models to determine the effects on gastric emptying and mixing. The reason for these relationships is unexplained and merit further investigation. |
| تدمد: | 2051-817X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1cff746704d5175bb831bcbdb912c3 https://doi.org/10.14814/phy2.14659 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9a1cff746704d5175bb831bcbdb912c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2051817X |
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