A meta-analysis of VDR polymorphisms and postmenopausal osteoporosis
| العنوان: | A meta-analysis of VDR polymorphisms and postmenopausal osteoporosis |
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| المؤلفون: | Jinhuan Ma, Sumei Yan, Qijun Si, Lijuan Fu |
| المصدر: | Endocrine Connections, Vol 9, Iss 9, Pp 882-889 (2020) Endocrine Connections |
| بيانات النشر: | Bioscientifica, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, gene polymorphisms, medicine.medical_specialty, TaqI, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Postmenopausal osteoporosis, Calcitriol receptor, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, Internal Medicine, Medicine, Allele, Genetic association, postmenopausal osteoporosis (pmop), lcsh:RC648-665, biology, business.industry, Research, vitamin d receptor (vdr), FokI, meta-analysis, 030104 developmental biology, chemistry, Meta-analysis, biology.protein, business |
| الوصف: | Background: Whether polymorphisms in VDR gene affect the risk of postmenopausal osteoporosis or not remain unclear. Thus, the authors performed a meta-analysis to more robustly assess associations between polymorphisms in VDR gene and the risk of postmenopausal osteoporosis by integrating the results of previous literature. Methods: Medline, Embase, Wanfang, VIP and CNKI were searched comprehensively for eligible literature, and 67 genetic association studies were finally selected to be included in this meta-analysis. Results: We found that ApaI rs7975232 (dominant comparison: OR = 0.77, P = 0.007; allele comparison: OR = 0.81, P = 0.04), BsmI rs1544410 (dominant comparison: OR = 0.69, P = 0.002; allele comparison: OR = 0.78, P = 0.008) and TaqI rs731236 (recessive comparison: OR = 1.32 , P = 0.01) polymorphisms were significantly associated with the risk of postmenopausal osteoporosis in Caucasians, whereas FokI rs10735810 polymorphism was significantly associated with the risk of postmenopausal osteoporosis in Asians (dominant comparison: OR = 0.61, P = 0.0001; recessive comparison: OR = 2.02, P = 0.001; allele comparison: OR = 0.68, P = 0.002). Conclusions: This meta-analysis shows that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms may affect the risk of postmenopausal osteoporosis in Caucasians, while BsmI rs1544410 polymorphism may affect the risk of postmenopausal osteoporosis in Asians. |
| اللغة: | English |
| تدمد: | 2049-3614 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a26e2a36b14042f60cc9bc4431be485 https://ec.bioscientifica.com/view/journals/ec/9/9/EC-20-0296.xml |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9a26e2a36b14042f60cc9bc4431be485 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20493614 |
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