Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder

التفاصيل البيبلوغرافية
العنوان: Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder
المؤلفون: Jose Luis Alatorre Warren, Alika K. Maunakea, Jacob Levman, Tadashi Shiohama, Briana Valli, Susan Faja, Emi Takahashi, Keita Tsujimura, Alpen Ortug
المصدر: Cereb Cortex
بيانات النشر: Oxford University Press, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Autism Spectrum Disorder, Cognitive Neuroscience, Nucleus accumbens, behavioral disciplines and activities, Nucleus Accumbens, Cerebral Ventricles, 03 medical and health sciences, Cellular and Molecular Neuroscience, Epilepsy, 0302 clinical medicine, mental disorders, medicine, Humans, Global developmental delay, Prospective Studies, Anterior cingulate cortex, 030304 developmental biology, Retrospective Studies, 0303 health sciences, medicine.diagnostic_test, business.industry, Brain morphometry, Infant, Newborn, Infant, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Autism spectrum disorder, Child, Preschool, Orbitofrontal cortex, Original Article, business, 030217 neurology & neurosurgery, Biomarkers
الوصف: Early interventions for autism spectrum disorder (ASD) are increasingly available, while only 42–50% of ASD children are diagnosed before 3 years old (YO). To identify neuroimaging biomarkers for early ASD diagnosis, we evaluated surface- and voxel-based brain morphometry in participants under 3YO who were later diagnosed with ASD. Magnetic resonance imaging data were retrospectively obtained from patients later diagnosed with ASD at Boston Children’s Hospital. The ASD participants with comorbidities such as congenital disorder, epilepsy, and global developmental delay/intellectual disability were excluded from statistical analyses. Eighty-five structural brain magnetic resonance imaging images were collected from 81 participants under 3YO and compared with 45 images from 45 gender- and age-matched nonautistic controls (non-ASD). Using an Infant FreeSurfer pipeline, 236 regionally distributed measurements were extracted from each scan. By t-tests and linear mixed models, the smaller nucleus accumbens and larger bilateral lateral, third, and fourth ventricles were identified in the ASD group. Vertex-wise t-statistical maps showed decreased thickness in the caudal anterior cingulate cortex and increased thickness in the right medial orbitofrontal cortex in ASD. The smaller bilateral accumbens nuclei and larger cerebral ventricles were independent of age, gender, or gestational age at birth, suggesting that there are MRI-based biomarkers in prospective ASD patients before they receive the diagnosis and that the volume of the nucleus accumbens and cerebral ventricles can be key MRI-based early biomarkers to predict the emergence of ASD.
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5e16bb33707a6dd76402bfc380e742
https://europepmc.org/articles/PMC8924432/
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....9a5e16bb33707a6dd76402bfc380e742
قاعدة البيانات: OpenAIRE