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Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol

التفاصيل البيبلوغرافية
العنوان: Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol
المؤلفون: R. B. Cope, R. Dashwood, C. Loehr, Nancy I. Kerkvliet
المصدر: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 5(5)
سنة النشر: 2006
مصطلحات موضوعية: Indoles, Skin Neoplasms, Ultraviolet Rays, Pharmacology, medicine.disease_cause, Toxicology, chemistry.chemical_compound, Mice, Indole-3-carbinol, medicine, Animals, Anticarcinogenic Agents, Physical and Theoretical Chemistry, Carcinogen, Tumor multiplicity, Mice, Hairless, Chlorophyllides, Chlorophyllin, Cancer, medicine.disease, Hairless, Diet, Cell Transformation, Neoplastic, chemistry, Female, Skin cancer, Carcinogenesis
الوصف: Over 1 million new cases of ultraviolet radiation-induced non-melanoma skin cancers (NMSC) per year now occur in the USA and the incidence of these diseases continues to increase. New preventative strategies are required. The hypothesis tested was that dietary administration of the putative cancer chemopreventatives sodium-copper-chlorophyllin (Chlor) or indole-3-carbinol (I3C) would inhibit UV-induced skin carcinogenesis in the Crl:SKH1:hr-BR hairless mouse. Groups of 20 mice were pre-fed isocaloric/isonutritive 20% corn-oil AIN-76a based diets that contained either Chlor (1.52 g%), I3C (5.08 g%) or no chemopreventative (control) for 2 weeks followed by exposure of their dorsal skin to a 10 week incremental, sub-erythemal, carcinogenic simulated solar UV exposure regime. Feeding was continued for the duration of the experiment. Matched non-UV exposed dietary groups were also included in the experimental design. The diets had no significant (p0.05) effect on body weight, feed consumption, cutaneous methanol-extractable UV photoprotective substances or on cutaneous UV-reflective characteristics. By day 180, UV-irradiated mice fed the Chlor had a significantly (p0.05) higher tumor multiplicity (33.6 +/- 4.72; mean +/- SEM) than UV-irradiated control animals (22.8 +/- 4.25). UV-irradiated mice fed I3C had a significantly (p0.001) lower tumor multiplicity (13.0 +/- 2.42) than that of both the UV-irradiated control and UV-irradiated Chlor-fed mice. The Chlor or I3C diets did not significantly (p0.05) affect UV-induced systemic suppression of contact hypersensitivity responses. These results demonstrate augmentation of the UV-induced cutaneous carcinogenic process by dietary chlorophyllin and protection from this carcinogenic process by indole-3-carbinol via mechanisms that do not involve changes in skin optical properties, modulation of photoimmunosuppression or caloric/nutrient effects.
تدمد: 1474-905X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa466c74f75ea46824e6e048459dd66
https://pubmed.ncbi.nlm.nih.gov/16685328
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....9aa466c74f75ea46824e6e048459dd66
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1474905X