Factors associated with graft survival in South African adolescent renal transplant patients at CMJAH over a 20‐year period (GRAFT‐SAT Study)
| العنوان: | Factors associated with graft survival in South African adolescent renal transplant patients at CMJAH over a 20‐year period (GRAFT‐SAT Study) |
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| المؤلفون: | Cecil Levy, Priya Darshani Chhiba, Claudia Do Vale, David P. Moore |
| المصدر: | Pediatric Transplantation. 26 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Graft Rejection, Male, medicine.medical_specialty, Multivariate analysis, Graft failure, Adolescent, Kaplan-Meier Estimate, South Africa, Risk Factors, Internal medicine, Outcome Assessment, Health Care, Humans, Medicine, Child, Proportional Hazards Models, Retrospective Studies, High rate, Transplantation, Proportional hazards model, business.industry, Graft Survival, Patient survival, Health Status Disparities, Kidney Transplantation, surgical procedures, operative, Renal transplant, Pediatrics, Perinatology and Child Health, Female, Graft survival, business, Developed country, Follow-Up Studies |
| الوصف: | BACKGROUND In the developed world, studies on transition of adolescent renal transplant patients have noted high rates of rejection, non-adherence and graft loss. There is a paucity of data in developing countries and none from South Africa. METHODS We evaluated patient and graft outcomes during adolescence (10-19 years), of patients who received a renal transplant over a 20-year period (1990-2010), at a tertiary hospital in Johannesburg. Cox proportional hazards models and Kaplan-Meier curves were used to analyse graft and patient survival. RESULTS A total of 213 kidney transplants were done in 162 patients during the study period, 165 transplants occurred during the adolescent period. Factors associated with graft failure on multivariate analysis included non-white race, transplant during the adolescent period ([aHR] 3.94; 95% [CI], 2.25-6.91), non-compliance with follow-up (aHR 3.89; 95% CI, 1.76-8.60) and receipt of a DD graft (aHR 2.10; 95% CI, 1.27-3.48). Patient survival rates at 1-, 3-, 5- and 10-years were 98.8%, 97.6%, 95.1% and 93.9% respectively. CONCLUSION High rates of graft rejection and loss occurred in South African renal transplant recipients in the adolescent period, especially in those retained in paediatric care. Establishment of transition clinics may improve the graft outcomes of this vulnerable group and warrant further research. |
| تدمد: | 1399-3046 1397-3142 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aac35074eff2f669be724e7a6fc23d1 https://doi.org/10.1111/petr.14148 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9aac35074eff2f669be724e7a6fc23d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993046 13973142 |
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