HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation
| العنوان: | HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation |
|---|---|
| المؤلفون: | Ravindra K. Gupta, Jonathan Lambert, John Frater, Hoi Ping Mok, Dimitra Peppa, Simon Edwards, Ian H Gabriel, Andrew J. Innes, Maria Salgado, Christopher Monit, Paul Grant, Eleni Nastouli, Helen Lee, Luke Muir, M Pace, Monique Nijhuis, Annemarie M. J. Wensing, Andrew M. L. Lever, Javier Martinez-Picado, Laura Waters, Fanny Salasc, Laura E. McCoy, Sultan Abdul-Jawad, Eduardo Olavarria |
| المساهمون: | Gupta, Ravindra [0000-0001-9751-1808], Mok, Hoi Ping [0000-0003-1402-7194], Salasc, Fanny [0000-0002-6574-1358], Apollo - University of Cambridge Repository |
| المصدر: | Nature |
| بيانات النشر: | Springer Nature, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, 0301 basic medicine, Receptors, CXCR4, Receptors, CCR5, General Science & Technology, Cytomegalovirus, HIV Infections, HIV Antibodies, gag Gene Products, Human Immunodeficiency Virus, Article, Virus, 03 medical and health sciences, 0302 clinical medicine, MD Multidisciplinary, Humans, Transplantation, Homologous, Medicine, Cytotoxic T cell, Multidisciplinary, biology, business.industry, Hematopoietic Stem Cell Transplantation, virus diseases, Total body irradiation, medicine.disease, Hodgkin Disease, Lymphoma, Transplantation, Haematopoiesis, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, HIV-1, biology.protein, Antibody, Stem cell, business |
| الوصف: | HIV-1 cure remains elusive with only one reported case a decade ago. Termed the “Berlin Patient”, the individual underwent 2 allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) procedures using a donor with a homozygous mutation in the HIV coreceptor CCR5 (CCR5Δ32/Δ32) to treat his acute myeloid leukemia. Total body irradiation was given with each HSCT. Critically, it is unclear which treatment or patient parameters contributed to this only documented case of long term HIV remission. Here we show that HIV-1 remission may be possible with a less aggressive and toxic approach. An HIV-1-infected adult underwent allo-HSCT for Hodgkin’s Lymphoma using cells from a CCR5Δ32/Δ32 donor. He experienced mild gut graft versus host disease. Antiretroviral therapy was interrupted 16 months after transplantation. HIV-1 remission has been maintained through a further 18 months. Plasma HIV-1 RNA has been undetectable at NIHR AmFAR |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9add19f87bf58ef7075a29171dc105c8 https://doi.org/10.1038/s41586-019-1027-4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9add19f87bf58ef7075a29171dc105c8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |