Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity
| العنوان: | Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity |
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| المؤلفون: | David Wojciechowski, Ivy A. Rosales, Shruti Gupta |
| المصدر: | Journal of Transplantation, Vol 2018 (2018) Journal of Transplantation |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, Article Subject, business.industry, Incidence (epidemiology), 030232 urology & nephrology, Urology, lcsh:Surgery, Renal function, lcsh:RD1-811, 030230 surgery, Belatacept, Kidney transplant, Tacrolimus toxicity, Tacrolimus, Calcineurin, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, business, medicine.drug, Research Article |
| الوصف: | Background. Calcineurin inhibitors are associated with chronic nephrotoxicity, manifesting as interstitial fibrosis/tubular atrophy (IF/TA) and arteriolar hyalinosis. Conversion from tacrolimus to belatacept may be one strategy to preserve renal function. Methods. We conducted a retrospective review of renal transplant patients followed at our institution who were converted to belatacept and found to have chronic tacrolimus toxicity on biopsy. The primary outcome was eGFR at conversion as compared to eGFR at 3, 6, 12, and 24 months after conversion. We also assessed incidence of infection and rates of allograft survival at 1 year. Results. The average time between transplant and conversion was 11.9 years. There was no decrease in eGFR at any postconversion time point as compared with preconversion. The mean eGFR at time of preconversion was 32.9 mL/min, as compared with 35.6 mL/min at 3 months (p=0.09), 34.1 mL/min at 6 months (p=0.63), 34.9 mL/min at 12 months (p=0.57), and 39.6 mL/min at 24 months after conversion (p=0.92). Four of 7 patients had increases in their eGFR after conversion. All grafts were functioning at 1 year after conversion. Conclusion. While this study was limited by a small number of patients, belatacept conversion stabilized eGFR at all time points in patients with late allograft function due to chronic tacrolimus toxicity, with a trend towards increased eGFR at 3 months. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2090-0015 2090-0007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae99765c0a75124b2626c88b82ddce8 https://doaj.org/article/05acac7779414f79ae6eeeaabe135054 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9ae99765c0a75124b2626c88b82ddce8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20900015 20900007 |
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