Quantitative 3D dynamic contrast‐enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking
| العنوان: | Quantitative 3D dynamic contrast‐enhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking |
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| المؤلفون: | Wei Yu, Yibin Xie, Debiao Li, Hyuk Jae Chang, Sang Eun Lee, Zhenjia Wang, Bill Zhou, Nan Wang, Zixin Deng, Anthony G. Christodoulou, Zhaoyang Fan |
| المصدر: | Magnetic Resonance in Medicine. 81:2302-2314 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Carotid Artery Diseases, Male, Carotid atherosclerosis, Time Factors, Intraclass correlation, Image quality, Normal Distribution, Contrast Media, Article, Imaging phantom, 030218 nuclear medicine & medical imaging, Motion, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Image Processing, Computer-Assisted, Humans, Human multitasking, Radiology, Nuclear Medicine and imaging, Aged, Mathematics, Aged, 80 and over, Reproducibility, Phantoms, Imaging, business.industry, Reproducibility of Results, Middle Aged, Magnetic Resonance Imaging, Mr imaging, Healthy Volunteers, Kinetics, Dynamic contrast, Carotid Arteries, Area Under Curve, Female, Nuclear medicine, business, Algorithms, 030217 neurology & neurosurgery |
| الوصف: | Author(s): Wang, Nan; Christodoulou, Anthony G; Xie, Yibin; Wang, Zhenjia; Deng, Zixin; Zhou, Bill; Lee, Sangeun; Fan, Zhaoyang; Chang, Hyukjae; Yu, Wei; Li, Debiao | Abstract: PurposeTo develop a dynamic contrast-enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1-based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique.Methods5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low-rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian-density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), vp , Ktrans , and ve were evaluated for each case.ResultsPhantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value ( R 2 = 0.96 ). In vivo studies demonstrated that AUC, vp , and Ktrans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P l 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P l 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: vp , 0.83; Ktrans , 0.87; ve , 0.92; AUC, 0.94).ConclusionMultitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall. |
| تدمد: | 1522-2594 0740-3194 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1a9ade80c18a1401648328adf1d6a9 https://doi.org/10.1002/mrm.27553 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9b1a9ade80c18a1401648328adf1d6a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222594 07403194 |
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