Gender difference in the impact of coexisting diabetes mellitus on long‐term clinical outcome in people with heart failure: a report from the Korean Heart Failure Registry
| العنوان: | Gender difference in the impact of coexisting diabetes mellitus on long‐term clinical outcome in people with heart failure: a report from the Korean Heart Failure Registry |
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| المؤلفون: | B.‐S. Yoo, S.‐M. Kang, S. Han, E.‐S. Jeon, K.‐H. Ryu, H.‐L. Kim, M.‐A. Kim, J.‐J. Kim, K.‐T. Park, Shung C. Chae, M.C. Cho, D.‐J. Choi, M.‐S. Shin |
| المصدر: | Diabetic Medicine. 36:1312-1318 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Comorbidity, Patient Readmission, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Endocrinology, Risk Factors, Sex factors, Internal medicine, Diabetes mellitus, Republic of Korea, Diabetes Mellitus, Internal Medicine, Clinical endpoint, Humans, Medicine, Registries, 030212 general & internal medicine, Aged, Aged, 80 and over, Heart Failure, business.industry, Incidence (epidemiology), Middle Aged, Prognosis, medicine.disease, Hospitalization, Heart failure, Female, business, Intensive management |
| الوصف: | Few data are available on the gender-related differences in the prognostic impact of diabetes in people with heart failure. This study was performed to investigate whether there is a gender difference in the association between diabetes and long-term clinical outcomes in people hospitalized for heart failure.A total of 3162 people hospitalized with heart failure (aged 67.4 ± 14.1 years, 50.4% females) from the data set of the nationwide registry were analysed. The primary endpoint was a composite of all-cause mortality and heart failure readmission.People with diabetes (30.5% for males vs. 31.1% for females, P = 0.740) were older and had more unfavourable risk factors and laboratory findings than those without diabetes in both genders. During a median follow-up period of 549 days, there were 1418 cases of composite events (44.8%). In univariable analysis, the coexistence of diabetes was significantly associated with a higher incidence of composite events in both genders (P 0.05 each for males and females). In multivariable analysis, the prognostic impact of diabetes on the development of composite events remained significant in females even after controlling for potential confounders (hazard ratio 1.43, 95% confidence intervals 1.12-1.84; P = 0.004). However, an independent association between diabetes and composite events was not seen in males in the same multivariable analysis (P 0.05).In people with heart failure, the impact of diabetes on long-term mortality and heart failure readmission seems to be stronger in females than in males. More careful and intensive management is needed especially in females with heart failure and diabetes. |
| تدمد: | 1464-5491 0742-3071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4d51fc173a98b0263ad2b166f13097 https://doi.org/10.1111/dme.14059 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9b4d51fc173a98b0263ad2b166f13097 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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