Residual Benign Prostate Glandular Tissue after Radical Prostatectomy is Not Associated with the Development of Detectable Postoperative Serum Prostate Specific Antigen
| العنوان: | Residual Benign Prostate Glandular Tissue after Radical Prostatectomy is Not Associated with the Development of Detectable Postoperative Serum Prostate Specific Antigen |
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| المؤلفون: | Scott A. Greenberg, Anobel Y. Odisho, Peter E. Lonergan, Jeffry P. Simko, Janet E. Cowan, Hao G. Nguyen, Peter R. Carroll, Avi Baskin, Samuel L. Washington |
| المصدر: | Journal of Urology. 206:706-714 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Biochemical recurrence, Surgical margin, medicine.medical_specialty, Neoplasm, Residual, Urology, medicine.medical_treatment, Risk Factors, Surgical oncology, Prostate, medicine, Humans, Postoperative Period, Prospective Studies, Aged, Prostatectomy, business.industry, breakpoint cluster region, Margins of Excision, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, Prostate-specific antigen, Treatment Outcome, medicine.anatomical_structure, Disease Progression, Kallikreins, Neoplasm Recurrence, Local, business, Benign prostate, Follow-Up Studies |
| الوصف: | To determine if benign glandular tissue at the surgical margin (BGM) is associated with detectable prostate specific antigen (PSA) and/or biochemical recurrence (BCR) after radical prostatectomy (RP).Participants underwent RP for localized prostate cancer between 2004 and 2018. Regression analysis was used to identify demographic, clinical and surgical factors associated with the likelihood of BGM presence on surgical pathology. Oncologic outcomes included detectable PSA (0.03 ng/ml), BCR (≥0.2 ng/ml) and progression to BCR or salvage treatment after detectable PSA. Life tables and Cox proportional hazards regression models were used to determine the association of BGM and risk of oncologic outcomes.A total of 1,082 men underwent RP for localized prostate cancer with BGM reported on surgical pathology and an undetectable postoperative PSA. BGM was present on 249 (23%) specimens. Younger age, bilateral nerve sparing surgery and robotic approach were associated with presence of BGM while malignancy at the surgical margin (MSM) was not. At 7 years after RP, 29% experienced detectable PSA and 11% had BCR. In the subgroup of men who reached detectable PSA, 79% had progression within 7 years. On multivariate Cox proportional hazards regression, BGM status was not independently associated with detectable PSA, BCR and/or progression from detectable PSA to BCR or salvage treatment.The presence of BGM at RP was not associated with increased risk of MSM, detectable PSA, BCR or progression after detectable PSA. |
| تدمد: | 1527-3792 0022-5347 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b826ce3bf3baaf54c3625df137c7059 https://doi.org/10.1097/ju.0000000000001793 |
| رقم الأكسشن: | edsair.doi.dedup.....9b826ce3bf3baaf54c3625df137c7059 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273792 00225347 |
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