From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM
| العنوان: | From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM |
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| المؤلفون: | S. R. King, A. Y. Oubré, G. M. Reaven, T. J. Carlson |
| المصدر: | Diabetologia. 40:614-617 |
| بيانات النشر: | Springer Science and Business Media LLC, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Drug, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Context (language use), Pharmacognosy, Pharmacology, law.invention, law, Internal Medicine, Humans, Hypoglycemic Agents, Medicine, Pharmaceutical sciences, media_common, Plants, Medicinal, Traditional medicine, business.industry, Blood Glucose Self-Monitoring, Reproducibility of Results, Diabetes Mellitus, Type 2, Drug development, Ethnobotany, Identification (biology), Medicine, Traditional, business, Phytotherapy |
| الوصف: | Pharmaceutical research conducted over the past three decades shows that natural products are a potential source of novel molecules for drug development [1, 2]. In this context, evidence has been published [3‐6] that a wide array of plant-derived active principles, representing numerous classes of chemical compounds, demonstrate activity consistent with their possible use in the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Among the classes of chemical compounds isolated from plants with documented biological activity are alkaloids, glycosides, galactomannan gum, polysaccharides, peptidoglycans, hypoglycans, guanidine, steroids, carbohydrates, glycopeptides, terpenoids, amino acids, and inorganic ions. Despite these interesting observations, to date, metformin is the only ethical drug approved for treatment of NIDDM derived from a medicinal plant historically used to treat diabetes. Why is this so, given the fact that higher plants are such a potential source of new drugs? The answer to this rhetorical question may lie in the reliance of most pharmaceutical companies on random, in vitro, mechanism-based, high throughput screening in the initial phases of plant drug research. In this article we will present the case for an alternative pathway to discovery of drugs for the treatment of NIDDM; one based on an ethnomedical approach, involving ethnobotany and traditional medicine. NIDDM as a disease of affluence: how could traditional medicine be relevant? |
| تدمد: | 1432-0428 0012-186X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9babb8cddf01b65256ea4b5cd412e94b https://doi.org/10.1007/s001250050724 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9babb8cddf01b65256ea4b5cd412e94b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320428 0012186X |
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