Facile protein conjugation of platinum for light-activated cytotoxic payload release
| العنوان: | Facile protein conjugation of platinum for light-activated cytotoxic payload release |
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| المؤلفون: | Peter B. O’Connor, Frederik Lermyte, Cinzia Imberti, Emily P Friar, Peter J. Sadler |
| المصدر: | Chemical Communications (Cambridge, England) |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Bioconjugation, 010405 organic chemistry, Lysine, Metals and Alloys, General Chemistry, Prodrug, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Amino acid, Chemistry, chemistry.chemical_compound, Myoglobin, chemistry, PEG ratio, Materials Chemistry, Ceramics and Composites, Side chain, Conjugate |
| الوصف: | The novel Pt(iv) complex trans,trans-[Pt(N3)2(Py)2(OH)(OCO-(PEG)2-NHCSNH-Ph-NCS)] (Pt4) conjugates to the side chain of lysine amino acids in proteins under mild conditions. Reaction with myoglobin generated a bioconjugate that was stable in the dark, but released a Pt(iv) prodrug upon visible light irradiation. A similar procedure was used to conjugate Pt4 to the antibody trastuzumab, resulting in the first photoactivatable Pt(iv)-antibody conjugate, demonstrating potential for highly selective cancer phototherapy. This platinum anticancer complex can be conjugated to proteins, including antibodies, under mild conditions and activated by visible light, providing a basis for highly selective cancer phototherapy. |
| تدمد: | 1364-548X 1359-7345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bad7fa1d45be1d53efa3be2f4ff66c2 https://doi.org/10.1039/d1cc02722k |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9bad7fa1d45be1d53efa3be2f4ff66c2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1364548X 13597345 |
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