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Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D

التفاصيل البيبلوغرافية
العنوان: Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D
المؤلفون: Manuel C. Maier, Marc Escribà-Gelonch, Heidrun Gruber-Woelfler, Maria Fernanda Neira d’Angelo, Volker Hessel, Timothy Noël
المساهمون: Micro Flow Chemistry and Synthetic Meth.
المصدر: Organic Process Research & Development, 22(2), 178-189. American Chemical Society
Organic Process Research & Development
سنة النشر: 2017
مصطلحات موضوعية: Vitamin, Materials science, Tandem, 010405 organic chemistry, Capillary action, Organic Chemistry, Analytical chemistry, 010402 general chemistry, 01 natural sciences, Article, 0104 chemical sciences, law.invention, Solvent, chemistry.chemical_compound, chemistry, law, Scientific method, Physical and Theoretical Chemistry, Crystallization, Acetonitrile, Filtration
الوصف: A continuous tandem in-line evaporation-crystallization is presented. The process includes an in-line solvent-swap step, suitable to be coupled to a capillary based cooler. As a proof of concept, this setup is tested in a direct in-line acetonitrile mediated crystallization of Vitamin D3. This configuration is suitable to be coupled to a new end-to-end continuous microflow synthesis of Vitamin D3. By this procedure, vitamin particles can be crystallized in continuous flow and isolated using an in-line continuous filtration step. In one run in just 1 min of cooling time, ∼50% (w/w) crystals of Vitamin D3 are directly obtained. Furthermore, the polymorphic form as well as crystals shape and size properties are described in this paper.
وصف الملف: application/pdf
تدمد: 1083-6160
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb28461342c36b426e21cc022e10d0a
https://pubmed.ncbi.nlm.nih.gov/29910596
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....9bb28461342c36b426e21cc022e10d0a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10836160