Lavender Products Associated With Premature Thelarche and Prepubertal Gynecomastia: Case Reports and Endocrine-Disrupting Chemical Activities
| العنوان: | Lavender Products Associated With Premature Thelarche and Prepubertal Gynecomastia: Case Reports and Endocrine-Disrupting Chemical Activities |
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| المؤلفون: | Kenneth S. Korach, J. Tyler Ramsey, Ajanta Naidu, Alejandro Diaz, Laurel A. Coons, Yin Li, Yukitomo Arao |
| المصدر: | The Journal of clinical endocrinology and metabolism, vol 104, iss 11 J Clin Endocrinol Metab |
| بيانات النشر: | The Endocrine Society, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, Lavandula, Clinical Biochemistry, Volatile, Lavender oil, Endocrine Disruptors, Biochemistry, Androgen, law.invention, Nuclear Receptor Coactivator 2, 030207 dermatology & venereal diseases, 0302 clinical medicine, Endocrinology, law, Receptors, Breast, Child, 0303 health sciences, Tumor, Gynecomastia, Female, medicine.medical_specialty, medicine.drug_class, Pediatric endocrinology, Clinical Sciences, Cell Line, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, 03 medical and health sciences, Internal medicine, medicine, Humans, Plant Oils, Endocrine system, Preschool, Clinical Research Articles, Essential oil, 030304 developmental biology, Breast development, business.industry, Puberty, Biochemistry (medical), Estrogen Receptor alpha, medicine.disease, Estrogen, Precocious, business, Oils |
| الوصف: | ContextPrevious case reports associated prepubertal gynecomastia with lavender-containing fragrances, but there appear to be no reports of premature thelarche.ObjectiveTo add to a case series about lavender-fragranced product use and breast growth in children and to measure endocrine-disrupting chemical activity of essential oil components.Design, Setting, and PatientsPatients experiencing premature thelarche or prepubertal gynecomastia with continuous exposure to lavender-fragranced products were evaluated in the pediatric endocrinology departments of two institutions. Mechanistic in vitro experiments using eight components of lavender and other essential oils were performed at National Institute of Environmental Health Sciences.Main Outcome MeasuresCase reports and in vitro estrogen and androgen receptor gene expression activities in human cell lines with essential oils.ResultsThree prepubertal girls and one boy with clinical evidence of estrogenic action and a history of continuous exposure to lavender-containing fragrances were studied. Breast growth dissipated in all patients with discontinuation of the fragranced products. Some of the components tested elicited estrogenic and antiandrogenic properties of varying degrees.ConclusionWe report cases of premature thelarche that resolved upon cessation of lavender-containing fragrance exposure commonly used in Hispanic communities. The precise developmental basis for such conditions could be multifactorial. In vitro demonstration of estrogenic and antiandrogenic properties of essential oil components suggests essential oils in these cases could be considered a possible source and supports a possible link with idiopathic prepubertal breast development. Whether the level of lavender oil estrogenic potency is sufficient to cause these effects is unknown. |
| وصف الملف: | application/pdf |
| تدمد: | 1945-7197 0021-972X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf96390a522a0a0aa186c9a758e1d93 https://doi.org/10.1210/jc.2018-01880 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9bf96390a522a0a0aa186c9a758e1d93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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