Simultaneous use of oxalate-degrading bacteria and herbal extract to reduce the urinary oxalate in a rat model: A new strategy
| العنوان: | Simultaneous use of oxalate-degrading bacteria and herbal extract to reduce the urinary oxalate in a rat model: A new strategy |
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| المؤلفون: | Mohammad Mehdi Feizabadi, Tahereh Safari, Mohammad Bokaeian, Alireza Ansari-Moghadam, Rouhi Afkari |
| المصدر: | International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International braz j urol v.45 n.6 2019 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology, Vol 45, Iss 6, Pp 1249-1259 (2019) |
| بيانات النشر: | FapUNIFESP (SciELO), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Time Factors, cationic protein, Normal diet, Urology, 030232 urology & nephrology, Urine, Pharmacology, Oxalate, Blood Urea Nitrogen, law.invention, Kidney Calculi, 03 medical and health sciences, Probiotic, chemistry.chemical_compound, 0302 clinical medicine, Reference Values, law, Lactobacillus, Tribulus, medicine, Animals, Rats, Wistar, Urtica dioica, Bifidobacterium, Hyperoxaluria, Oxalates, biology, Plant Extracts, business.industry, Probiotics, Reproducibility of Results, Jeevaneeya Rasayana [Supplementary Concept], biology.organism_classification, medicine.disease, Diseases of the genitourinary system. Urology, Kidney Tubules, chemistry, Creatinine, 030220 oncology & carcinogenesis, Calcium, Original Article, human [Supplementary Concept], Kidney stones, RC870-923, urate-calcium oxalate stone, business |
| الوصف: | Objective: Urinary stones with oxalate composition can cause kidney failure. Recent findings evidenced that probiotics are effective in reducing oxalate absorption in these subjects based on their high colonic absorption levels at baseline. The purpose of this study was to evaluate the effect of the simultaneous use of oxalate-degrading bacteria, Urtica dioica and T. terrestris extract in reducing urinary oxalate. Materials and Methods: Anti-urolithiatic activity of Urtica dioica and T. terrestris extract and probiotic by using ethylene glycol induced rat model. In this study, 4 strains of Lactobacillus and 2 strains of Bifidobacterium and also 2 strains of L. paracasei (that showed high power in oxalate degrading in culture media) were used. Male Wistar rats were divided into four groups (n=6). The rats of group-I received normal diet (positive control group) and groups-II (negative control group), III, IV rats received diet containing ethylene glycol (3%) for 30 days. Groups III rats received Urtica dioica and T. terrestris extract. Groups IV rats received extracts + probiotic for 30 days. Findings: The results show that the use of herbal extracts (Urtica dioica and T. terrestris) reduced the level of urinary oxalate and other parameters of urine and serum. Also, the accumulation of calcium oxalate crystals in the kidney tissue was significantly reduced. Conclusion: Considering that the formation of calcium oxalate crystals can cause inflammation and tissue damage in the kidney, the use of herbal extracts with oxalate degrading bacteria can be a new therapeutic approach to preventing the formation of kidney stones. |
| وصف الملف: | text/html |
| تدمد: | 1677-6119 1677-5538 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c88596ab9c9e5392f4c2191035d23c6 https://doi.org/10.1590/s1677-5538.ibju.2019.0167 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9c88596ab9c9e5392f4c2191035d23c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16776119 16775538 |
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