High Plasma Levels of Endothelin-1 and Atrial Natriuretic Peptide in Patients With Acute Ischemic Stroke
| العنوان: | High Plasma Levels of Endothelin-1 and Atrial Natriuretic Peptide in Patients With Acute Ischemic Stroke |
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| المؤلفون: | Vicente Estrada, M. J. Téllez, Jose Antonio Egido, A F Fernández Cruz, J Moya, R Fernández-Durango |
| المصدر: | American Journal of Hypertension. 7:1085-1089 |
| بيانات النشر: | Oxford University Press (OUP), 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Infarction, Peptide hormone, Brain Ischemia, Atrial natriuretic peptide, Internal medicine, Blood plasma, Internal Medicine, medicine, Humans, Stroke, Aged, Aged, 80 and over, Neurologic Examination, Cerebral infarction, business.industry, Endothelins, Cerebral Infarction, Middle Aged, medicine.disease, Endothelin 1, Cerebrovascular Disorders, Endocrinology, Acute Disease, Cardiology, Female, Endothelin receptor, business, Atrial Natriuretic Factor |
| الوصف: | The plasma levels of endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) have been measured in 37 patients with acute ischemic stroke, on admission and 3 and 7 days thereafter. The plasma ET-1 levels at the onset of symptoms were about two-fold those observed in age-matched normal volunteers (3.5 +/- 2.26 v 1.54 +/- 0.9 pg/mL, respectively; P.001). These levels remained significantly elevated during the 7-day study period. The neurologic deficit was assessed daily by Mathew's modified scale (MS). A significant correlation was found between neurologic status on admission and ET-1 plasma values; patients with worse neurologic status (MS45 points) had higher ET-1 plasma values than those with better neurologic status (MS45 points) (5.4 +/- 2.34 v 3.05 +/- 2.04 pg/mL, respectively, P.05). The plasma ET-1 values did not correlate either with the site of the infarction or with its primary cause (cardioembolic, lacunar, or atherothrombotic). No significant differences were seen in plasma ET-1 concentrations between patients who eventually died and those who survived the acute event. The plasma ANP were about 18-fold higher in ischemic stroke patients on admission than in controls at admission (110.9 +/- 29.5 v 5.84 +/- 3.96 pg/mL, respectively, P.01). These values remained significantly elevated on days 3 and 7. There was no correlation between the ANP plasma values and the neurologic status, the site or mechanism of the stroke, or the plasma ET-1 levels. In conclusion, ischemic stroke is associated with marked acute and long-duration increases of ET-1 and ANP.(ABSTRACT TRUNCATED AT 250 WORDS) |
| تدمد: | 1941-7225 0895-7061 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdf7f069ec0d9e7e64799f89dd0cb32 https://doi.org/10.1093/ajh/7.12.1085 |
| رقم الأكسشن: | edsair.doi.dedup.....9cdf7f069ec0d9e7e64799f89dd0cb32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19417225 08957061 |
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