Cytoplasmic-only Expression of Maspin Predicts Unfavorable Prognosis in Patients With Pancreatic Ductal Adenocarcinoma
| العنوان: | Cytoplasmic-only Expression of Maspin Predicts Unfavorable Prognosis in Patients With Pancreatic Ductal Adenocarcinoma |
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| المؤلفون: | Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Ei Uchinaka, Yoshihisa Umekita, Yoshiyuki Fujiwara, Takehiko Hanaki, Tomohiko Sakabe |
| المصدر: | Anticancer Research. 41:2543-2552 |
| بيانات النشر: | Anticancer Research USA Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Cytoplasm, Cancer Research, Pancreatic ductal adenocarcinoma, endocrine system diseases, Adenocarcinoma, Cell Line, Tumor, Biomarkers, Tumor, Humans, Medicine, Neoplasm Invasiveness, In patient, Serpins, Aged, Cell Proliferation, Cell invasion, business.industry, Maspin, General Medicine, Transfection, Middle Aged, Subcellular localization, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Oncology, Cancer research, Female, business, Carcinoma, Pancreatic Ductal |
| الوصف: | Background/aim Maspin is a tumor-suppressor protein expressed in >90% of pancreatic ductal adenocarcinoma (PDAC) cases. We aimed to assess the prognostic value of subcellular localization of maspin. Patients and methods Ninety-two resected PDAC specimens were immunohistochemically analyzed. Cytoplasmic-only expression observed in >10% of the tumor was defined as maspin-positive. Results The maspin-positive status (21.7%) was inversely correlated with well-differentiated histological type and indicated a shorter recurrence-free survival (RFS) and overall survival (OS). Cox's multivariate analysis showed that maspin-positive status was an independent factor for shorter RFS and OS. Maspin was localized to cytoplasm in AsPC-1 cells, but to both nucleus and cytoplasm in BxPC-3 cells. In AsPC-1 cells, cell invasion was significantly reduced in response to maspin suppression via transfection with siRNA targeting maspin, whereas no reduction was observed in BxPC-3 cells. Conclusion Cytoplasmic-only expression of maspin could be an independent unfavorable prognostic indicator for patients with PDAC. |
| تدمد: | 1791-7530 0250-7005 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf94e5e13ec39b7447cf9bbaddae649 https://doi.org/10.21873/anticanres.15032 |
| رقم الأكسشن: | edsair.doi.dedup.....9cf94e5e13ec39b7447cf9bbaddae649 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917530 02507005 |
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