Downregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injury
| العنوان: | Downregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injury |
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| المؤلفون: | Patricia K. Eagon, Stasa Tadic, Mary S. Elm, Amin A. Nanji |
| المصدر: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 281:G342-G349 |
| بيانات النشر: | American Physiological Society, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Physiology, medicine.drug_class, Down-Regulation, Estrogen receptor, Biology, Physiology (medical), Internal medicine, medicine, Animals, Testosterone, Rats, Wistar, Liver Diseases, Alcoholic, Cell Nucleus, Liver injury, Estradiol, Hepatology, Gastroenterology, Ceruloplasmin, Sex hormone receptor, Androgen, medicine.disease, Dietary Fats, Rats, Androgen receptor, Endocrinology, Receptors, Estrogen, Receptors, Androgen, Sex steroid, Estrogen, Hormone |
| الوصف: | Chronic ethanol ingestion in rats and humans results in significant alterations in sex steroid levels and expression of sex hormone-dependent phenotype. In this study, we used the intragastric feeding model in male rats to determine hepatic sex hormone receptor activity under circumstances of chronic ethanol exposure and differing degrees of liver injury induced by type of dietary fat. Pathological analysis and quantitation of hepatic androgen receptor (AR) and estrogen receptor (ER) activity, serum sex hormones, and sex hormone-responsive protein and mRNA expression were performed. The activity of the physiologically relevant nuclear form of both AR and ER was significantly decreased with ethanol and correlated inversely with the severity of liver injury. Serum testosterone levels, as well as expression of an androgen-dependent hepatic mRNA, were decreased by ethanol and progressive liver injury. Serum estradiol increased with liver injury. We postulate that these changes in receptor activity may be due to the oxidative stress, reduced cellular energy, and/or altered cytokine milieu known to occur in this model. |
| تدمد: | 1522-1547 0193-1857 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4ce726cd3e1ab6166a65298600616d https://doi.org/10.1152/ajpgi.2001.281.2.g342 |
| رقم الأكسشن: | edsair.doi.dedup.....9d4ce726cd3e1ab6166a65298600616d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221547 01931857 |
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