FXR Protects Lung from Lipopolysaccharide-Induced Acute Injury
| العنوان: | FXR Protects Lung from Lipopolysaccharide-Induced Acute Injury |
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| المؤلفون: | Donna Yu, Wendong Huang, Lisheng Zhang, Tao Li, Barry M. Forman |
| المصدر: | Molecular Endocrinology. 26:27-36 |
| بيانات النشر: | The Endocrine Society, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Lipopolysaccharides, Lipopolysaccharide, Acute Lung Injury, Receptors, Cytoplasmic and Nuclear, Lung injury, Biology, Proinflammatory cytokine, Mice, chemistry.chemical_compound, Endocrinology, Parenchyma, medicine, Animals, Lung, Molecular Biology, Cell Proliferation, Mice, Knockout, medicine.diagnostic_test, Tumor Necrosis Factor-alpha, Forkhead Box Protein M1, Endothelial Cells, Forkhead Transcription Factors, Pneumonia, General Medicine, respiratory system, Special Features, respiratory tract diseases, Mice, Inbred C57BL, P-Selectin, Bronchoalveolar lavage, medicine.anatomical_structure, chemistry, Immunology, Cancer research, Tumor necrosis factor alpha, Farnesoid X receptor, Bronchoalveolar Lavage Fluid, Cell Adhesion Molecules |
| الوصف: | Acute lung injury and its more severe form, acute respiratory distress syndrome, are characterized by an acute inflammatory response in the airspaces and lung parenchyma. The nuclear receptor farnesoid X receptor (FXR) is expressed in pulmonary artery endothelial cells. Here, we report a protective role of FXR in a lipopolysaccharide-induced mouse model of acute lung injury. Upon intratracheal injection of lipopolysaccharide, FXR-/- mice showed higher lung endothelial permeability, released more bronchoalveolar lavage cells to the alveoli, and developed acute pneumonia. Cell adhesion molecules were expressed at higher levels in FXR-/- mice as compared with control mice. Furthermore, lung regeneration was much slower in FXR-/- mice. In vitro experiments showed that FXR activation blocked TNFα-induced expression of P-selectin but stimulated proliferation of lung microvascular endothelial cells through up-regulation of Foxm1b. In addition, expression of a constitutively active FXR repressed the expression of proinflammatory genes and improved lung permeability and lung regeneration in FXR-/- mice. This study demonstrates a critical role of FXR in suppressing the inflammatory response in lung and promoting lung repair after injury. |
| تدمد: | 1944-9917 0888-8809 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6d36e1d3ba6808d8168aee7402577d https://doi.org/10.1210/me.2011-0042 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9d6d36e1d3ba6808d8168aee7402577d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19449917 08888809 |
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