The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice
| العنوان: | The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice |
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| المؤلفون: | Zachary Margulies, Yang Song, Didier A. Depireux, Sunayana Mitra, Virginia E. Drake, Beatrice Milon, Ryan Casserly, Ronna Hertzano, Jessica A. Mong |
| المصدر: | Biology of Sex Differences, Vol 9, Iss 1, Pp 1-14 (2018) Biology of Sex Differences |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Hearing loss, Male mice, Physiology, lcsh:Medicine, Protective Agents, ABR, lcsh:Physiology, Gender Studies, 03 medical and health sciences, Mice, 0302 clinical medicine, Endocrinology, Sex differences, Inner ear, medicine, Evoked Potentials, Auditory, Brain Stem, otorhinolaryngologic diseases, Animals, Sex Characteristics, Vorinostat, lcsh:QP1-981, business.industry, Research, lcsh:R, SAHA, Biological sex, medicine.disease, Sexual dimorphism, 030104 developmental biology, medicine.anatomical_structure, Hearing Loss, Noise-Induced, Female, Hair cell, medicine.symptom, Noise-induced hearing loss, business, Noise, B6CBAF1/J mice, 030217 neurology & neurosurgery, Sex characteristics |
| الوصف: | Background Noise-induced hearing loss (NIHL) is the most prevalent form of acquired hearing loss and affects about 40 million US adults. Among the suggested therapeutics tested in rodents, suberoylanilide hydroxamic acid (SAHA) has been shown to be otoprotective from NIHL; however, these results were limited to male mice. Methods Here we tested the effect of SAHA on the hearing of 10-week-old B6CBAF1/J mice of both sexes, which were exposed to 2 h of octave-band noise (101 dB SPL centered at 11.3 kHz). Hearing was assessed by measuring auditory brainstem responses (ABR) at 8, 16, 24, and 32 kHz, 1 week before, as well as at 24 h and 15–21 days following exposure (baseline, compound threshold shift (CTS) and permanent threshold shift (PTS), respectively), followed by histologic analyses. Results We found significant differences in the CTS and PTS of the control (vehicle injected) mice to noise, where females had a significantly smaller CTS at 16 and 24 kHz (p |
| اللغة: | English |
| تدمد: | 2042-6410 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd0275a4c83c80b34e3f041520d354f http://link.springer.com/article/10.1186/s13293-018-0171-0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9dd0275a4c83c80b34e3f041520d354f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20426410 |
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