Surface Enrichment and Depletion of the Active Ingredient in Spray Dried Amorphous Solid Dispersions
العنوان: | Surface Enrichment and Depletion of the Active Ingredient in Spray Dried Amorphous Solid Dispersions |
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المؤلفون: | Zhen Chen, Alan Zhu, Lian Yu, Feng Qian, Chengbin Huang, Kuan Yang |
المصدر: | Pharmaceutical Research. 35 |
بيانات النشر: | Springer Science and Business Media LLC, 2018. |
سنة النشر: | 2018 |
مصطلحات موضوعية: | Pyrrolidines, Vinyl Compounds, Surface Properties, Chemistry, Pharmaceutical, Drug Compounding, Diffusion, Indomethacin, Pharmaceutical Science, macromolecular substances, 02 engineering and technology, 030226 pharmacology & pharmacy, Excipients, Surface tension, 03 medical and health sciences, 0302 clinical medicine, Pharmacology (medical), Fluconazole, Wilhelmy plate, Pharmacology, chemistry.chemical_classification, Chemistry, Organic Chemistry, technology, industry, and agriculture, Polymer, 021001 nanoscience & nanotechnology, Amorphous solid, Chemical engineering, Spray drying, Molecular Medicine, Nimodipine, Polyvinyls, 0210 nano-technology, Dispersion (chemistry), Hydrophobic and Hydrophilic Interactions, Melting-point depression, Biotechnology |
الوصف: | To study the effects of physicochemical properties of drug and polymer, as well as the drug-polymer interactions, on the surface composition of SDDs. Ethanol solutions containing a model drug (IMC, NMP or FCZ) and a model polymer (PVPK12, PVPK30 or PVP-VA) were spray dried, and the surface composition of SDDs was analyzed by XPS. The surface tensions of pure components and their solutions were measured using Wilhelmy plate and/or calculated using ACD/Labs. NMR and DLS were used to obtain the diffusion coefficients of IMC, NMP, PVPK12 and PVPK30 in solvents. Flory-Huggins interaction parameters for selected drug-polymer pairs were obtained using a melting point depression method. Significant surface enrichment or depletion of the drug was observed in SDDs depending on the particular drug-polymer combination. With PVP as the dispersion polymer, IMC and NMP were surface enriched; whereas FCZ, a hydrophilic drug, was surface depleted. With increasing PVP molecular weight, the surface drug concentration increased, and the effect was greater in the NMP/PVP and FCZ/PVP systems than in the IMC/PVP system where strong drug-polymer interaction existed. Changing the polymer from PVP to PVP-VA reduced the surface concentration of the drug. The surface concentration of a SDD can be significantly different from the bulk concentration. The main results of this work are consistent with the notion that the relative surface tensions control surface enrichment or depletion. Besides, the relative diffusion rates of the components and the strength of their interactions may also affect the surface composition of the SDDs. |
تدمد: | 1573-904X 0724-8741 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df5a589f6aa510ca0e404ff548f4d42 https://doi.org/10.1007/s11095-018-2345-1 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....9df5a589f6aa510ca0e404ff548f4d42 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 1573904X 07248741 |
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