α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression
| العنوان: | α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression |
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| المؤلفون: | Montana Upton, Shahrdad Lotfipour |
| المصدر: | Biochemical Pharmacology, vol 97, iss 4 Upton, M; & Lotfipour, S. (2015). α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression. Biochemical Pharmacology, 97(4), 558-565. doi: 10.1016/j.bcp.2015.06.015. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7n68s66r Biochemical pharmacology, vol 97, iss 4 Upton, M; & Lotfipour, S. (2015). α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression. Biochemical Pharmacology. doi: 10.1016/j.bcp.2015.06.015. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3tx3r7t9 |
| بيانات النشر: | eScholarship, University of California, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Hippocampus, Receptors, Nicotinic, Nicotinic, Biochemistry, Nicotine, Mice, Nicotine withdrawal, Mesencephalon, Receptors, Limbic System, Premovement neuronal activity, Hippocampal, 2.1 Biological and endogenous factors, Pharmacology & Pharmacy, Aetiology, Mice, Knockout, Neurons, Neuronal activity, Substance Abuse, CA1 Region, Tobacco Use Disorder, Pharmacology and Pharmaceutical Sciences, Nicotinic agonist, Anesthesia, Neurological, Proto-Oncogene Proteins c-fos, medicine.drug, Biotechnology, Interpeduncular nucleus, Drug Abuse (NIDA Only), Knockout, 1.1 Normal biological development and functioning, Addiction, Biology, Basic Behavioral and Social Science, Article, Midbrain, Underpinning research, Behavioral and Social Science, Tobacco, medicine, Genetics, Animals, CA1 Region, Hippocampal, Pharmacology, Chrna2, Tobacco Smoke and Health, Dentate gyrus, Neurosciences, medicine.disease, Brain Disorders, Good Health and Well Being, Gene Expression Regulation, nervous system, Biochemistry and Cell Biology, Neuroscience |
| الوصف: | © 2015 Elsevier Inc. All rights reserved. Neuronal nicotinic acetylcholine receptors (nAChRs) are the primary binding sites for nicotine within the brain. Using alpha(α)2 nAChR subunit-null mutant mice, the current study evaluates whether the absence of this gene product during mecamylamine-precipitated nicotine withdrawal eliminates neuronal activity within selective midbrain and limbic brain regions, as determined by the expression of the immediate early gene, cfos. Our results demonstrate that nicotine withdrawal enhances neuronal activity within the interpeduncular nucleus and dorsal hippocampus, which is absent in mice null for α2-containing nAChRs. In contrast, we observe that α2-null mutant mice exhibit a suppression of neuronal activity in the dentate gyrus in mice undergoing nicotine withdrawal. Interestingly, α2-null mutant mice display potentiated neuronal activity specifically within the stratum lacunosum moleculare layer of the hippocampus, independent of nicotine withdrawal. Overall, our findings demonstrate that α2-null mutant mice have altered cfos expression in distinct populations of neurons within selective midbrain and limbic brain structures that mediate baseline and nicotine withdrawal-induced neuronal activity. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e39d33b88b41119fb211aec1d3fecc1 https://escholarship.org/uc/item/7n68s66r |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9e39d33b88b41119fb211aec1d3fecc1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |