New prognostic model for synchronous metastatic renal cell carcinoma
| العنوان: | New prognostic model for synchronous metastatic renal cell carcinoma |
|---|---|
| المؤلفون: | Mayu Yagi, Masayuki Kurokawa, Tomoyuki Kato, Toshihiko Sakurai, Atsushi Yamagishi, Hayato Nishida, Takuya Yamanobe, Yuya Kuboki, Michinobu Ozawa, Yuta Kurota, Osamu Ichiyanagi, Hiroki Fukuhara, Takafumi Narisawa, Hidenori Kanno, Norihiko Tsuchiya, Sei Naito, Masaki Ushijima |
| المصدر: | International Journal of Urology. 27:448-456 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Urology, medicine.medical_treatment, 030232 urology & nephrology, Nephrectomy, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Internal medicine, medicine, Carcinoma, Humans, Risk factor, Carcinoma, Renal Cell, Retrospective Studies, Kidney, business.industry, Hazard ratio, Prognosis, medicine.disease, Kidney Neoplasms, Confidence interval, medicine.anatomical_structure, 030220 oncology & carcinogenesis, business |
| الوصف: | Objectives To create a new model for the prediction of overall survival in synchronous metastatic renal cell carcinoma. Methods Medical records of 158 patients with metastatic renal cell carcinoma diagnosed at the Yamagata University Hospital from August 2007 to February 2018 were reviewed. Among them, 77 with synchronous metastatic renal cell carcinoma were retrospectively analyzed using the univariate and multivariate analyses. A new prognostic model was constructed, followed by a bootstrap validation to estimate the model fitting. In addition, these prognostic factors were estimated in 67 metachronous metastatic renal cell carcinoma patients. Results Five independent prognostic factors were identified in synchronous metastatic renal cell carcinoma: cT3/4, cN1, high corrected calcium, >3.6 neutrophil-to-lymphocyte ratio and central nerve system metastasis. The number (%) and overall survival (95% confidence interval) in the favorable- (0 or 1 risk factor), intermediate- (2 risk factors) and poor-risk (≥3 risk factors) groups were 29 (45.3%) and 67.4 (31.8-NA), 21 (32.8%) and 16.8 (10.0-27.6), and 14 (21.9%) and 9.1 (7.3-13.7) months, respectively. The C-index was 0.72. Patients in the favorable-risk group had better overall survival with nephrectomy than without nephrectomy (hazard ratio 0.29, 95% confidence interval 0.09-0.91 with nephrectomy). In metachronous metastatic renal cell carcinoma, these prognostic factors showed no statistical differences in the overall survival. Conclusions Prognostic factors are completely different between synchronous and metachronous metastatic renal cell carcinoma. The new model for synchronous metastatic renal cell carcinoma can predict a good candidate for cytoreductive nephrectomy. |
| تدمد: | 1442-2042 0919-8172 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e80aa15078289b66f14d926011aa2ed https://doi.org/10.1111/iju.14215 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9e80aa15078289b66f14d926011aa2ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14422042 09198172 |
|---|