In Vivo Bioluminescence Imaging of Cobalt Accumulation in a Mouse Model
| العنوان: | In Vivo Bioluminescence Imaging of Cobalt Accumulation in a Mouse Model |
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| المؤلفون: | Wei He, Lin Ma, Minyong Li, Deying Gong, Xueyan Gou, Bowen Ke, Ting Kang, Lupei Du |
| المصدر: | Analytical Chemistry. 90:4946-4950 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | inorganic chemicals, High selectivity, chemistry.chemical_element, Mice, Transgenic, Oxidative phosphorylation, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, Mice, Luciferases, Firefly, In vivo, Animals, Bioluminescence, Bioluminescence imaging, Bond cleavage, Fluorescent Dyes, 010405 organic chemistry, Optical Imaging, Cobalt, 0104 chemical sciences, chemistry, Luminescent Measurements, Models, Animal, Biophysics, Preclinical imaging |
| الوصف: | As a trace element nutrient, cobalt is critical for both prokaryotes and eukaryotes. In the current study, a turn-on Cobalt Bioluminescent Probe 1 (CBP-1) for the detection of cobalt has been successfully developed based on oxidative C–O bond cleavage. This probe exhibited high selectivity and sensitivity toward cobalt over other analytes. By using CBP-1, the successful in vivo imaging of cobalt accumulation was carried out in a mouse model. Such an ability to determine cobalt in living animals provides a powerful technology for studying the system distribution, toxic potency, and biological effect of Co2+. |
| تدمد: | 1520-6882 0003-2700 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8ccba1bb2b723fb9e9476006d0bbbe https://doi.org/10.1021/acs.analchem.8b00391 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9e8ccba1bb2b723fb9e9476006d0bbbe |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206882 00032700 |
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