Current understanding of insulin resistance in hepatitis C
| العنوان: | Current understanding of insulin resistance in hepatitis C |
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| المؤلفون: | V. Kaddai, Francesco Negro |
| المصدر: | Expert Review of Gastroenterology & Hepatology. 5:503-516 |
| بيانات النشر: | Informa UK Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Hepatitis C virus, Type 2 diabetes, Carbohydrate metabolism, medicine.disease_cause, Antiviral Agents, Mice, Insulin resistance, Fibrosis, Internal medicine, medicine, Animals, Humans, Glucose homeostasis, Hepatology, biology, business.industry, Gastroenterology, Interferon-alpha, virus diseases, Hepatitis C, medicine.disease, Insulin receptor, Glucose, Endocrinology, Diabetes Mellitus, Type 2, Immunology, biology.protein, Female, Insulin Resistance, business, Signal Transduction |
| الوصف: | Important breakthroughs have been made in recent years into understanding the close interaction between hepatitis C virus (HCV) infection and glucose homeostasis. Both cross-sectional and longitudinal studies have demonstrated that infection with HCV is associated with an increased risk of developing insulin resistance and Type 2 diabetes. A direct effect of HCV on hepatocyte insulin signaling has been shown in experimental models. Some preliminary observations seem to suggest that indirect mechanisms involving extrahepatic organs might also play a role. The interaction between HCV and glucose metabolism has significant clinical consequences. Insulin resistance and Type 2 diabetes not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the virological response to IFN-α-based therapy. Thus, understanding the mechanisms underlying HCV-associated glucose metabolism derangements is of paramount interest in order to improve the clinical management of chronic hepatitis C. This article will focus on the studies that consistently argue in favor of an interrelation between HCV and insulin resistance and will highlight the latest discoveries in this field. |
| تدمد: | 1747-4132 1747-4124 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9e743370d9489aa58005fb371d55c0 https://doi.org/10.1586/egh.11.43 |
| رقم الأكسشن: | edsair.doi.dedup.....9e9e743370d9489aa58005fb371d55c0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17474132 17474124 |
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