Evolution and extensive reassortment of H5 influenza viruses isolated from wild birds in China over the past decade
| العنوان: | Evolution and extensive reassortment of H5 influenza viruses isolated from wild birds in China over the past decade |
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| المؤلفون: | Xianying Zeng, Shujie Ma, Chengjun Li, Yongping Jiang, Pucheng Chen, Yuntao Guan, Guobin Tian, Fei Wang, Yanbing Li, Li Jiang, Xiaoli Bai, Yulei Li, Yanpeng Ci, Lu Zhao, Yanfang Cui, Hongmei Bao, Yasuo Suzuki, Pengfei Cui, Hualan Chen, Jianzhong Shi, Liling Liu, Jingman Tian, Guohua Deng, Zhiyuan Qu, Jinxiong Liu, Minghui Li, Deli Wang, Xiaomei Chen, Cen Yang, Xiurong Wang, Shanshan Wu |
| المصدر: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, China, Genotype, Epidemiology, viruses, 030106 microbiology, Immunology, Reassortment, Virulence, Animals, Wild, Chick Embryo, Biology, medicine.disease_cause, Microbiology, Evolution, Molecular, Mice, 03 medical and health sciences, Virology, Drug Discovery, Influenza A virus, medicine, Lethal infection, Animals, Influenza A Virus, H5N8 Subtype, Clade, wild birds, Mice, Inbred BALB C, Influenza A Virus, H5N1 Subtype, Outbreak, Articles, General Medicine, Influenza A virus subtype H5N1, virulence, Ducks, 030104 developmental biology, Infectious Diseases, H5 subtype, reassortant, Influenza in Birds, Female, Parasitology, Influenza A Virus, H5N2 Subtype, Chickens, Reassortant Viruses, Research Article |
| الوصف: | Lethal infection of wild birds with different subtypes of H5 viruses continuously occur. To investigate the genetic evolution and pathogenicity of H5 viruses in wild birds, we performed a detailed genetic and biologic analysis of 27 viruses, including H5N1, H5N2, H5N6, and H5N8 subtypes, that were responsible for avian influenza outbreaks in wild birds in China over the past decade. We found that these 27 viruses, bearing different clades/subclades of HA, were complicated reassortants and formed 12 different genotypes. Ten of the viruses tested were highly pathogenic in chickens, but showed distinct pathotypes in ducks and mice. Five of these 10 viruses, which were all from clade2.3.4.4, could bind human-type receptors. Our findings reveal the diversity of the genetic and biologic properties of H5 viruses circulating in wild birds and highlight the need to carefully monitor and evaluate the risks these viruses pose to animal and public health. |
| تدمد: | 2222-1751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eebcd54438a603c16b8ebe97ec62c36 https://doi.org/10.1080/22221751.2020.1797542 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9eebcd54438a603c16b8ebe97ec62c36 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 22221751 |
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