Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule
| العنوان: | Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule |
|---|---|
| المؤلفون: | Thiago R.L.C. Paixão, Luís Moreira Gonçalves, Leigh Aldous, Nikola Tasić, Alnilan Lobato, Bassim Mounssef, Adriano O. Maldaner, Ataualpa A. C. Braga, Renata A Grothe |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Polymers, Benzocaine, 02 engineering and technology, 01 natural sciences, Biochemistry, Analytical Chemistry, Molecular Imprinting, Molecular recognition, Cocaine, Molecularly Imprinted Polymers, Electrochemistry, medicine, Environmental Chemistry, Electrodes, Voltammetry, Spectroscopy, Detection limit, Chromatography, ELETROANÁLISE, Chemistry, 010401 analytical chemistry, Molecularly imprinted polymer, Electrochemical Techniques, 021001 nanoscience & nanotechnology, Potentiostat, 0104 chemical sciences, Cyclic voltammetry, 0210 nano-technology, Molecular imprinting, medicine.drug |
| الوصف: | The analysis of 'cutting' or additive agents in cocaine, like benzocaine (BZC), allows police analysts to identify each component of the sample, thus obtaining information like the drugs' provenience. This kind of drug profiling is of great value in tackling drug trafficking. Electropolymerized molecularly imprinted polymers (e-MIPs) on portable screen-printed carbon electrodes (SPCEs) were developed in this study for BZC determination. The MIPs' electropolymerization was performed on a carbon surface using the anaesthetic BZC as the template molecule and 3-amino-4-hydroxybenzoic acid (3,4-AHBA) as the functional monomer. The build-up of this biomimetic sensor was carefully characterized by cyclic voltammetry (CV) and optimized. Cyclic voltammetric investigation demonstrated that BZC oxidation had a complex and pH-dependent mechanism, but at pH 7.4 a single, well-defined oxidation feature was observed. The BZC-MIP interactions were studied by computer-aided theoretical modeling by means of density functional theory (DFT) calculations. The electroanalytical methodology was effectively applied to artificial urine samples; BZC molecular recognition was achieved with a low limit of detection (LOD) of 2.9 nmol L-1 employing square-wave voltammetry (SWV). The e-MIPs were then used to 'fingerprint' genuine cocaine samples, assisted by principal component analysis (PCA), at the central forensic laboratory of the Brazilian Federal Police (BFP) with a portable potentiostat. This electroanalysis provided proof-of-concept that the drugs could be voltammetrically 'fingerprinted' using e-MIPs supported by chemometric analysis. |
| تدمد: | 1364-5528 0003-2654 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef3be5bd467738197cea0f683eba3fe https://doi.org/10.1039/d0an02274h |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9ef3be5bd467738197cea0f683eba3fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13645528 00032654 |
|---|