Regional differences in prevalence of HIV-1 discordance in Africa and enrollment of HIV-1 discordant couples into an HIV-1 prevention trial
| العنوان: | Regional differences in prevalence of HIV-1 discordance in Africa and enrollment of HIV-1 discordant couples into an HIV-1 prevention trial |
|---|---|
| المؤلفون: | Connie Celum, Susan Allen, Mubiana Inambao, James Kiarie, Patrick Ndase, Nelly Mugo, Linda Kavuma, Jairam R. Lingappa, Elizabeth A. Bukusi, David Coetzee, Sinead Delany-Moretlwe, Amalia Magaret, Andrew Mujugira, Guy de Bruyn, Kenneth Ngure, Joseph Makhema, Rachel Manongi, Edwin Were, Barrot H. Lambdin, William Kanweka |
| المساهمون: | Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences |
| المصدر: | PLoS One PLoS ONE, Vol 3, Iss 1, p e1411 (2008) PLoS ONE |
| بيانات النشر: | University of Cape Town, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, Sexual transmission, Palliative care, Voluntary counseling and testing, Psychological intervention, lcsh:Medicine, Zambia, HIV Infections, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), HIV Seronegativity, Epidemiology, Prevalence, Humans, Medicine, Uganda, 030212 general & internal medicine, Circumcision for HIV prevention, lcsh:Science, 030505 public health, Multidisciplinary, business.industry, Incidence (epidemiology), lcsh:R, 1. No poverty, virus diseases, Infectious Diseases/HIV Infection and AIDS, medicine.disease, Kenya, 3. Good health, Sexual Partners, Public and occupational health, Immunology, Africa, HIV-1, lcsh:Q, 0305 other medical science, business, Serostatus, Research Article, Demography |
| الوصف: | Background Most HIV-1 transmission in Africa occurs among HIV-1-discordant couples (one partner HIV-1 infected and one uninfected) who are unaware of their discordant HIV-1 serostatus. Given the high HIV-1 incidence among HIV-1 discordant couples and to assess efficacy of interventions for reducing HIV-1 transmission, HIV-1 discordant couples represent a critical target population for HIV-1 prevention interventions and prevention trials. Substantial regional differences exist in HIV-1 prevalence in Africa, but regional differences in HIV-1 discordance among African couples, has not previously been reported. Methodology/Principal Findings The Partners in Prevention HSV-2/HIV-1 Transmission Trial (“Partners HSV-2 Study”), the first large HIV-1 prevention trial in Africa involving HIV-1 discordant couples, completed enrollment in May 2007. Partners HSV-2 Study recruitment data from 12 sites from East and Southern Africa were used to assess HIV-1 discordance among couples accessing couples HIV-1 counseling and testing, and to correlate with enrollment of HIV-1 discordant couples. HIV-1 discordance at Partners HSV-2 Study sites ranged from 8–31% of couples tested from the community. Across all study sites and, among all couples with one HIV-1 infected partner, almost half (49%) of couples were HIV-1 discordant. Site-specific monthly enrollment of HIV-1 discordant couples into the clinical trial was not directly associated with prevalence of HIV-1 discordance, but was modestly correlated with national HIV-1 counseling and testing rates and access to palliative care/basic health care (r = 0.74, p = 0.09). Conclusions/Significance HIV-1 discordant couples are a critical target for HIV-1 prevention in Africa. In addition to community prevalence of HIV-1 discordance, national infrastructure for HIV-1 testing and healthcare delivery and effective community outreach strategies impact recruitment of HIV-1 discordant couples into HIV-1 prevention trials. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef66232f1657085b87f9b3cfdd672b7 https://hdl.handle.net/11427/16151 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9ef66232f1657085b87f9b3cfdd672b7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |