Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance
| العنوان: | Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance |
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| المؤلفون: | Matteo Serino, Elodie Luche, F Ortega, Gerard Pardo, Gema Frühbeck, Javier Salvador, J M Moreno-Navarrete, Aurélie Waget, José Manuel Fernández-Real, Wifredo Ricart, Rémy Burcelin |
| المصدر: | International Journal of Obesity |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Adipose tissue, Enzyme-Linked Immunosorbent Assay, 030209 endocrinology & metabolism, Body Mass Index, Mice, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Text mining, Weight loss, health services administration, Internal medicine, Weight Loss, medicine, Animals, Humans, Obesity, 030304 developmental biology, Inflammation, 0303 health sciences, Membrane Glycoproteins, Nutrition and Dietetics, biology, business.industry, pathological conditions, signs and symptoms, medicine.disease, nervous system diseases, body regions, Cross-Sectional Studies, Endocrinology, Adipose Tissue, Spain, biology.protein, population characteristics, Female, Insulin Resistance, medicine.symptom, Carrier Proteins, business, Lipopolysaccharide binding protein, Body mass index, Biomarkers, Acute-Phase Proteins |
| الوصف: | Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice.Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 μg ml(-1), P0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration.LBP is an inflammatory marker associated with obesity-related insulin resistance. |
| تدمد: | 1476-5497 0307-0565 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef9bedb295e7eca3a9c7b14385a6dba https://doi.org/10.1038/ijo.2011.256 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9ef9bedb295e7eca3a9c7b14385a6dba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765497 03070565 |
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