Redox imbalance induced by docetaxel in the neuroblastoma SH-SY5Y cells: a study of docetaxel-induced neuronal damage
| العنوان: | Redox imbalance induced by docetaxel in the neuroblastoma SH-SY5Y cells: a study of docetaxel-induced neuronal damage |
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| المؤلفون: | Giulia Collodel, Daniela Cerretani, Elena Moretti, Andrea Menchiari, Daria Noto, Lucia Micheli, Cinzia Signorini, Sergio Crispino |
| المصدر: | Redox Report, Vol 26, Iss 1, Pp 18-28 (2021) Redox Report : Communications in Free Radical Research article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, cellular antioxidants, SH-SY5Y, Physiology, QH301-705.5, Clinical Biochemistry, 030204 cardiovascular system & hematology, Biochemistry, Redox, Antioxidants, Apoptosis, SH-SY5Y cells, chemobrain, docetaxel, isoprostanes, transmission electron microscopy, tubulin, Neuroblastoma, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Pathology, Humans, RB1-214, Biology (General), F2-Isoprostanes, 030102 biochemistry & molecular biology, biology, Chemistry, Biochemistry (medical), apoptosis, Cancer, Cell Biology, medicine.disease, Isoprostanes, Tubulin, Docetaxel, Cancer research, biology.protein, sh-sy5y cells, Oxidation-Reduction, Research Article, medicine.drug |
| الوصف: | Objectives In cancer survivors, chemotherapy-associated adverse neurological effects are described as side effects in non-targeted tissue. We investigated the role of redox-imbalance in neuronal damage by a relative low dose of Docetaxel (DTX). Methods The neuroblastoma cells (SH-SY5Y cells) were exposed to DTX at a dose of 1.25 nM for 6 h. Antioxidant defenses (i.e. ascorbic acid, glutathione, and catalase) and lipid oxidation products (i.e. F2-isoprostanes) were evaluated. To investigate cell ultrastructure and tubulin localisation, transmission electron microscopy (TEM) and immunofluorescence techniques were applied. Results In the SH-SY5Y cells, DTX induced a significant reduction of total glutathione (P |
| اللغة: | English |
| تدمد: | 1743-2928 1351-0002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f047256fc55f3b293c6a4b40a1b5674 https://doaj.org/article/69b5ffd6a1384a16bb4f7880b5dd2293 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9f047256fc55f3b293c6a4b40a1b5674 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17432928 13510002 |
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