The Association Between Trace Elements Exposure and the Cognition in the Elderly in China
| العنوان: | The Association Between Trace Elements Exposure and the Cognition in the Elderly in China |
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| المؤلفون: | Kaichun Li, Jinhui Yu, Yong Fan, Fangbiao Tao, Linsheng Yang, Li Wang, Guimei Chen, Annuo Liu, Sufang Wang, Xiude Li, Ling Gu, Hongjuan Cao, Jie Sheng, Qunan Wang, Dongmei Zhang, Ying Ma, Kaiyong Liu |
| المصدر: | Biological Trace Element Research. 199:403-412 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | China, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Protective factor, chemistry.chemical_element, 010501 environmental sciences, Logistic regression, 01 natural sciences, Biochemistry, Gastroenterology, Inorganic Chemistry, 03 medical and health sciences, Cognition, Internal medicine, medicine, Humans, Aged, 0105 earth and related environmental sciences, Whole blood, Manganese, 0303 health sciences, business.industry, 030302 biochemistry & molecular biology, Biochemistry (medical), Cobalt, General Medicine, Odds ratio, Middle Aged, Additional research, Trace Elements, chemistry, Quartile, Thallium, business |
| الوصف: | This study aimed to evaluate the association between aluminum (Al), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), selenium (Se), strontium (Sr), thallium (Tl), and vanadium (V) levels in whole blood and the cognitive ability of people over 60 years old. A total of 1217 eligible participants were enrolled in our study in Lu'an city, Anhui province, China. The inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the concentration of nine trace elements in the whole blood, which reflect their exposure levels. Mini-mental State Examination (MMSE) scale was employed to screen the cognitive function of the elderly. Logistic regression was applied to assess the associations of nine whole blood trace elements with cognition. In the work, it has found that high levels of whole blood As and Se are risk factors for cognitive dysfunction. As and Se quartile were correlated with increased risk of cognitive dysfunction, and with the odds ratio (OR) of 2.06 (95% CI 1.30-3.25; p-trend = 0.002), 1.947 (95% CI 1.20-3.17; p-trend = 0.007) in the highest quartile. However, high concentration of Al, V, and Ba in whole blood were protective factors for cognitive function [OR = 0.63 (95% CI 0.40-0.98; p-trend = 0.040), 0.549 (95% CI 0.36-0.85; p-trend = 0.007), 0.460 (95% CI 0.28-0.75; p-trend = 0.002) respectively]. The study suggested that the exposure of some trace elements (As, Se) were associated with the increased risk of cognitive dysfunction; on the contrary, other elements (Al, V, Ba) could be protective factor for cognitive function. These findings need to be confirmed in additional research of a large elderly population. |
| تدمد: | 1559-0720 0163-4984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f363f50f4d5e9f07916739e75bfdfb1 https://doi.org/10.1007/s12011-020-02154-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9f363f50f4d5e9f07916739e75bfdfb1 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15590720 01634984 |
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