Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation
| العنوان: | Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation |
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| المؤلفون: | Gordon J. Freeman, John F. Daley, Vassiliki A. Boussiotis, John G. Gribben, Gary S. Gray, Lee M. Nadler |
| المصدر: | Proceedings of the National Academy of Sciences. 90:11059-11063 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Interleukin 2, Receptor complex, Immunoconjugates, Time Factors, T-Lymphocytes, T cell, Antigen presentation, Receptors, Antigen, B-Cell, chemical and pharmacologic phenomena, Biology, Lymphocyte Activation, Abatacept, Antigen, Antigens, CD, medicine, Humans, CTLA-4 Antigen, Receptors, Immunologic, Antigen-presenting cell, B-Lymphocytes, Multidisciplinary, Receptor Aggregation, Antibodies, Monoclonal, CD28, T lymphocyte, Flow Cytometry, Antigens, Differentiation, Cell biology, medicine.anatomical_structure, Immunology, B7-1 Antigen, Interleukin-2, Research Article, medicine.drug |
| الوصف: | Signaling via the T-cell receptor complex is necessary but not sufficient to induce antigen-specific T lymphocytes to expand clonally. To proliferate, T cells must receive one or more costimulatory signals provided by antigen presenting cells (APCs). One such critical costimulatory signal is delivered by the CD28/CTLA-4 counterreceptor, B7, expressed on APCs. B7 costimulation induces CD28 signaling, resulting in interleukin 2 (IL-2) secretion, and T-cell proliferation. Conversely, T-cell receptor signaling in the absence of B7 costimulation results in induction of antigen-specific tolerance. Here, we show that activated human B lymphocytes express two additional CTLA-4 counterreceptors also capable of providing T-cell costimulation. At 24 hr postactivation, B cells express a CTLA-4 counterreceptor not recognized by anti-B7 or -BB-1 monoclonal antibodies (mAbs), which induces detectable IL-2 secretion and T-cell proliferation. At 48 and 72 hr postactivation, B cells express both B7 and a third CTLA-4 counterreceptor identified by the anti-BB-1 mAb. BB-1 appears to be a molecule distinct from B7 by its expression on B7- cells and its capacity to induce T cells to proliferate without significant accumulation of IL-2. As observed for B7, costimulatory signals mediated by these alternative CTLA-4/CD28 counterreceptors are likely to be essential for generation of an immune response and their absence may result in antigen-specific tolerance. We propose the following terminology for these CTLA-4 counterreceptors: (i) B7, B7-1; (ii) early CTLA-4 binding counterreceptor, B7-2; and (iii) BB-1, B7-3. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3bd8bd2d29e6024878de5cdff47bc1 https://doi.org/10.1073/pnas.90.23.11059 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9f3bd8bd2d29e6024878de5cdff47bc1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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