Access to essential anticancer medicines for children and adolescents in Europe
| العنوان: | Access to essential anticancer medicines for children and adolescents in Europe |
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| المؤلفون: | Karsten Nysom, Pamela Kearns, S. Griskjane, Gilles Vassal, G. Bricalli, L. Kameric, F. Arnold, Anita Kienesberger, S. Kamal, Olga Kozhaeva, Nicola Jane Latino, N. Cherny, L. Basset |
| المصدر: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, MECANICA DE LOS MEDIOS CONTINUOS Y TEORIA DE ESTRUCTURAS, 10.- Reducir las desigualdades entre países y dentro de ellos, medicine.medical_specialty, Adolescent, Public policy, Organizational model, Pharmacist, Economic shortage, Medical Oncology, Health Services Accessibility, World health, Essential medicines, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Anticancer medication, 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades, Humans, Medicine, Child, Paediatric oncology, business.industry, Infant, Newborn, Infant, Out-of-pocket, Hematology, Pain management, Europe, 030104 developmental biology, Clinical research, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Family medicine, Health Expenditures, Medication shortage, Drugs, Essential, business |
| الوصف: | [EN] Background: Essential anticancer medicines are an indispensable component of multidisciplinary treatment of paediatric malignancies. A European Society for Medical Oncology (ESMO) study reported inequalities in the availability of anticancer medicines for adult solid tumours and provided a model for the present survey. The aim of this survey was to assess the accessibility of essential medicines used in paediatric cancer patients aged 0 to 18 years across Europe from 2016 to 2018. Methods: A list of medicines was drawn with input from the European Society for Paediatric Oncology (SIOP Europe) Clinical Research Council referring to the World Health Organization Model List of Essential Medicines for Children (WHO EMLc) 2017. A survey was sent to nominated national clinician and pharmacist rapporteurs and parent associations in up to 37 countries; answers were obtained from 34 countries. Results: The full survey list contained 68 medicines, including 24 on the WHO EMLc 2017. Health professionals reported that 35% of all medicines were prescribed off-label in at least one country and that 44% were always available in >90% of countries. Only 63% of the EMLc 2017 medicines were reported as always available. The main determinant of unavailability was shortages, reported for 72% of medicines in at least one country. Out-of-pocket costs were reported in eight countries. Twenty-seven percent of orally administered medicines were never available in childfriendly formulations. Parents detailed individual efforts and challenges of facilitating ingestion of oral medicines as prescribed. Inequalities in access to pain control during procedures were reported by parents across Europe. Conclusions: Children and adolescents with cancer in Europe experience lack of access to essential medicines. Urgent actions are needed to address shortages, financial accessibility, availability of safe age-appropriate oral formulations, and pain management across Europe. This work was supported by the EU Health Programme (2014-2020) in the framework of the Joint Action on Rare Cancers [grant number 724161/JARC]. |
| وصف الملف: | application/pdf |
| تدمد: | 0923-7534 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f71b35b522b5be1e834fe003dd4d82e https://doi.org/10.1016/j.annonc.2020.12.015 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9f71b35b522b5be1e834fe003dd4d82e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237534 |
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