Anti-inflammatory secondary metabolites from Scrophularia kotschyana
| العنوان: | Anti-inflammatory secondary metabolites from Scrophularia kotschyana |
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| المؤلفون: | Büşra Korkmaz, Merve Kılıç, Hasan Kırmızıbekmez, Gülin Renda, Mine Kadioglu |
| المصدر: | Human & Experimental Toxicology. 40:S676-S683 |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Formalin Test, biology, Traditional medicine, medicine.drug_class, Health, Toxicology and Mutagenesis, Ethyl acetate, General Medicine, Toxicology, biology.organism_classification, Anti-inflammatory, chemistry.chemical_compound, Chromatographic separation, chemistry, Apigenin, medicine, Scrophularia, Luteolin, Dichloromethane |
| الوصف: | The species belonging to Scrophularia genus grow mainly in Irano-Turanian and Mediterranean regions and have been used as folk remedy for inflammatory-related diseases since ancient times. The present study was aimed to evaluate the anti-inflammatory activity of the extracts of Scrophularia kotschyana as well as the isolated compounds. The aerial parts and the roots of the plant were separately extracted with methanol. Anti-inflammatory activities of both extracts were evaluated with formalin test in mice. As the methanolic extract of the aerial parts significantly ( p < .05) inhibited inflammation, it was then submitted to successive solvent extractions with n-hexane, dichloromethane, ethyl acetate and n-butanol to yield subextracts. Anti-inflammatory activities of the subextracts were evaluated within the same test system. Among the subextracts tested, the n-butanol subextract produced a significant ( p < .05) anti-inflammatory activity at all doses (5, 10, and 30 mg/kg, ip.). Sequential chromatographic separation of the n-butanol subextract yielded 8-O-acetyl-4′- O-( E)- p-coumaroylharpagide, 8- O-acetyl-4′- O-( Z)- p-coumaroylharpagide, β-sitosterol 3- O-β-glucopyranoside, apigenin 7- O-β-glucopyranoside, apigenin 7- O-rutinoside, luteolin 7- O-β-glucopyranoside and luteolin 7- O-rutinoside. The anti-inflammatory activities of the isolates were evaluated at 5 mg/kg dose. Luteolin 7- O-β-glucopyranoside and apigenin 7- O-rutinoside caused a significant ( p < .05) inhibition of oedema formation. |
| تدمد: | 1477-0903 0960-3271 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8b18f93469757c784169c1e094a2d4 https://doi.org/10.1177/09603271211058889 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9f8b18f93469757c784169c1e094a2d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770903 09603271 |
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