A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers
| العنوان: | A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
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| المؤلفون: | Zheng-Tao Zhao, Rui-Ding Li, Wen-Xuan Zheng, Ning Meng, Wen-Jun Zhu, Quanyang Li, Qin-Ren Zhang, Xiao-Lin Liang, Li-Hua Mei |
| المصدر: | Nutrients, Vol 13, Iss 3891, p 3891 (2021) Nutrients Volume 13 Issue 11 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Lactobacillus casei, Lactobacillus casei LTL1879, Physiology, Gut flora, law.invention, Superoxide dismutase, Probiotic, chemistry.chemical_compound, healthy young people, law, Lactobacillus, Medicine, TX341-641, oxidant, Bifidobacterium, Nutrition and Dietetics, biology, gut microbiota, business.industry, blood biochemical, Nutrition. Foods and food supply, Clostridium leptum, food and beverages, biology.organism_classification, Malondialdehyde, chemistry, probiotics, inflammation, biology.protein, business, Food Science |
| الوصف: | Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of Lactobacillus casei LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (p < 0.0001), while malondialdehyde (MDA) levels decreased (p < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (p < 0.05, respectively). Escherichia coli, Enterococcus, and Bacteroides expression was significantly reduced (p < 0.05), while Clostridium leptum, Bifidobacterium, and Lactobacillus expression increased (p < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group’s overall score was higher than that of the placebo group. The results of this pilot study suggest L. casei LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd1a1afd0c1345af0adff0e283d936e https://www.mdpi.com/2072-6643/13/11/3891 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9fd1a1afd0c1345af0adff0e283d936e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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