Development of the Eurotransplant Discard Risk Index to Predict Acceptance of Livers for Transplantation: A Retrospective Database Analysis
| العنوان: | Development of the Eurotransplant Discard Risk Index to Predict Acceptance of Livers for Transplantation: A Retrospective Database Analysis |
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| المؤلفون: | Jacob D. de Boer, Simen D van den Berg, Markus Guba, Andries E. Braat, Nouvel A Cambridge, Hein Putter, Serge Vogelaar, Gabriela A. Berlakovich, Joris J. Blok |
| المصدر: | Experimental and Clinical Transplantation, 19(11), 1163-1172. BASKENT UNIV |
| بيانات النشر: | Baskent University, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Donor Selection, Retrospective database, Primary outcome, Risk Factors, Diabetes mellitus, Internal medicine, Risk index, Humans, Medicine, Stage (cooking), Retrospective Studies, Cause of death, Transplantation, Liver transplantation, business.industry, Graft Survival, Organ allocation, medicine.disease, Tissue Donors, Organ procurement, Treatment Outcome, Liver, business, Body mass index |
| الوصف: | Objectives: The utilization of liver allografts could be optimized if nonacceptance is predicted. This study aimed to evaluate the prognostic ability of an updated Discard Risk Index in Eurotransplant.Materials and Methods: Potential deceased donors from January 2010 to December 2015 who had been reported to Eurotransplant were included in our analyses. Liver utilization was defined by transplant status as the primary outcome to evaluate the performance of the Eurotransplant-developed Discard Risk Index.Results: Of 11 670 potential livers, 9565 (81%) were actually transplanted. Donor sex, age, history of diabetes, drug abuse, use of vasopressors, body mass index category, serum sodium, cause of death, donor type, and levels of C-reactive protein, bilirubin, aspartate and alanine aminotransferases, international normalized ratio, and gamma-glutamyl transpeptidase were associated with discard and combined in the Eurotransplant-developed Discard Risk Index. Correlation between the two Discard Risk Indexes was high (r = 0.86), and both achieved high C statistics of 0.72 and 0.75 (P |
| تدمد: | 2146-8427 1304-0855 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd37560c62dbaff128714c72336cb19 https://doi.org/10.6002/ect.2021.0228 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9fd37560c62dbaff128714c72336cb19 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21468427 13040855 |
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