Hashimoto’s thyroiditis worsens ovaries in polycystic ovary syndrome patients compared to Anti-Müllerian hormone levels
| العنوان: | Hashimoto’s thyroiditis worsens ovaries in polycystic ovary syndrome patients compared to Anti-Müllerian hormone levels |
|---|---|
| المؤلفون: | Özer Birge, Feyza Tekeli, Aliye Nigar Serin, Aysel Uysal, Suheyla Gorar |
| المصدر: | BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-8 (2021) BMC Endocrine Disorders |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Anti-Mullerian Hormone, endocrine system, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Autoimmunity, 030209 endocrinology & metabolism, Ovary, Hashimoto Disease, Anti-Müllerian hormone, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Thyroiditis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, Ovarian Reserve, Ovarian reserve, Polycystic ovary syndrome, lcsh:RC648-665, 030219 obstetrics & reproductive medicine, biology, business.industry, Hashimoto’s thyroiditis, General Medicine, medicine.disease, Antral follicle, Polycystic ovary, female genital diseases and pregnancy complications, Anti-thyroid autoantibodies, Premature ovarian failure, Endocrinology, medicine.anatomical_structure, biology.protein, Female, business, Research Article |
| الوصف: | Background The human ovary is the target of autoimmune attack in cases of autoimmune disorders, which can cause ovarian dysfunction. Due to the higher prevalence of Hashimoto’s Thyroiditis (HT) in Polycystic Ovary Syndrome (PCOS) patients, we aimed to evaluate ovarian reserve and the effect of autoimmune exposure time on ovarian reserve in PCOS patients with HT by Anti-Müllerian hormone (AMH) levels. Methods Forty-six PCOS patients and 46 PCOS with HT diagnosed patients who are between 18 and 35 years old were recruited for this study. Detailed medical histories were obtained from all participants. Polycystic ovary image was evaluated and antral follicles were counted by transvaginal ultrasound. Modified Ferriman Gallwey score, body mass index, waist/hip ratio of the patients were examined. Hormonal, biochemical profiles and AMH levels of the patients were evaluated during the early follicular phase. The data of both groups were statistically analyzed with SPSS 18.0. Results 20 (43.5%) patients in the PCOS group were fertile, 8 (17.4%) patients in the PCOS + HT group were fertile, fertility rate was significantly lower in PCOS + HT group. The mean AMH value was 8.8 ± 8.8 in the PCOS + HT group and 12.4 ± 8.1 in the PCOS group and it was significantly lower in the PCOS + HT group (p = 0.043). AMH values were significantly negatively correlated with anti-thyroid peroxidase antibody (anti-TPO) level and the duration of HT. There was a significant positive correlation between the anti-TPO level and the duration of HT. Conclusıon We pointed out that the coexistence of PCOS and HT, two prevalent diseases of reproductive age, further diminished ovarian reserve. More exposure of the ovaries to autoantibodies can cause ovarian destruction, similar to the thyroid gland like HT. Because of all these close relations with PCOS and thyroid dysfunctions, we recommend evaluating both thyroid autoantibodies and hormone levels in PCOS patients at the first visit. Patients with PCOS + HT should be monitored more closely to determine the fertility treatment options and control premature ovarian failure (POF) table. |
| تدمد: | 1472-6823 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd94b3480089561761b0592f57f301b https://doi.org/10.1186/s12902-021-00706-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9fd94b3480089561761b0592f57f301b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14726823 |
|---|