Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers
| العنوان: | Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers |
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| المؤلفون: | Christopher Schütze, Andreas Gleiss, Kata Miháltz, Pia Veronika Vécsei-Marlovits, Florian Sulzbacher, Birgit Weingessel |
| المصدر: | Journal of Ophthalmology, Vol 2018 (2018) Journal of Ophthalmology |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Article Subject, genetic structures, Long term follow up, Diabetic macular edema, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Ophthalmology, Ophthalmology, Medicine, business.industry, Retinal, eye diseases, Hyperreflective foci, Clinical trial, 030104 developmental biology, chemistry, lcsh:RE1-994, 030221 ophthalmology & optometry, Intravitreal ranibizumab, Ranibizumab, business, Research Article, medicine.drug |
| الوصف: | Purpose. Long-term follow-up of patients with diabetic macular edema (DME) treated with intravitreal antivascular endothelial growth factor (anti-VEGF) combined focal laser and identification of prognostic morphological characteristics. Methods. Prospective clinical trial (50 treatment-naive eyes) with DME randomized 1 : 1 receiving intravitreal ranibizumab (0.5 mg/0.05 ml) and prompt grid laser compared with ranibizumab and deferred laser. Morphological characteristics potentially relevant for prognosis were assessed at baseline, month 6, month 9, and years 1, 2, 3, 4, and 5 of follow-up. Results. Although functional results were slightly higher in the prompt group at week 12 (0.5; 20/40 Snellen (SD = 0.04, 0.3 logMAR) versus 0.4; 20/50 Snellen (SD = 0.04, logMAR: 0.4), p=0.4) and month 9 (prompt group: 0.5; 20/40 Snellen (SD = 0.03, 0.3 logMAR) versus deferred group: 0.4; 20/50 Snellen (SD = 0.04, 0.4 logMAR), p=0.4), these were statistically insignificant. There was no significant benefit regarding functionality during long-term follow-up in the prompt group compared to the deferred group. BCVA in the eyes with clusters of hyperreflective foci in the central macular region was inferior compared with the eyes without these alterations at year 5 (0.39; 20/50 Snellen, (SD = 0.25, 0.4 logMAR) versus 0.63; 20/80 Snellen (SD = 0.22, 0.2 logMAR), p<0.01). Conclusion. Grid laser and ranibizumab therapy are effective in DME management during the long-term follow-up. Intraretinal hyperreflective material in SD-OCT is negatively related to BCVA. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2090-0058 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00591d3f331b3439f4b37c5c37752ea https://doaj.org/article/63020fea642c4ba383f38fd9bbf2ba33 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a00591d3f331b3439f4b37c5c37752ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20900058 |
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