The human melanoma proteome atlas—Defining the molecular pathology
| العنوان: | The human melanoma proteome atlas—Defining the molecular pathology |
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| المؤلفون: | Marie Sjögren, Lázaro Betancourt, Natália Pinto de Almeida, Charlotte Welinder, Jeovanis Gil, Uğur Çakır, Madalina Oppermann, Elisabet Wieslander, Roger Appelqvist, Ken Miller, David Fenyö, Carina Eriksson, Leticia Szadai, Matilda Marko-Varga, A. Marcell Szász, Toshihide Nishimura, Peter Horvatovich, Erika Velasquez, Luiciana Pizzatti, Sarolta Kárpáti, Peter Horvath, Henrik Lindberg, Viktória Doma, Christian Ingvar, Magdalena Kuras, Nicole Woldmar, Jimmy Rodriguez Murillo, Gilberto B. Domont, István Németh, Yonghyo Kim, Runyu Hong, Indira Pla Parada, Håkan Olsson, Johan Malm, Ho Jeong Kwon, Fábio C. S. Nogueira, Yutaka Sugihara, Erik Steinfelder, Jonatan Eriksson, Bo Baldetorp, Ethan Berge, Aniel Sanchez, József Tímár, Krzysztof Pawłowski, Tasso Miliotis, György Marko-Varga, Henriett Oskolas, Francesco Florindi, Dasol Kim, Lotta Lundgren, Melinda Rezeli, Boram Lee, Beatrice S. Knudsen, Harubumi Kato, Henrik Ekedahl, Qimin Zhou, Beáta Szeitz |
| المساهمون: | Analytical Biochemistry, Medicinal Chemistry and Bioanalysis (MCB) |
| المصدر: | Clinical and Translational Medicine Clinical and Translational Medicine, 11(7):e473. John Wiley & Sons Ltd. Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Proteomics, Medicine (General), medicine.medical_specialty, Skin Neoplasms, Proteome, Medicine (miscellaneous), metastatic malignant melanoma, Biology, Young Adult, R5-920, Tandem Mass Spectrometry, Cell Line, Tumor, subcellular localization, Human proteome project, medicine, Humans, Melanoma, Research Articles, Chromatography, High Pressure Liquid, Aged, Aged, 80 and over, Molecular pathology, Cancer, Middle Aged, medicine.disease, Subcellular localization, Proteogenomics, proteogenomics, Cancer research, histopathology, Molecular Medicine, Histopathology, Female, heterogeneity, Research Article |
| الوصف: | The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in‐depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients. The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in‐depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and sub‐cellular localization was annotated within both primary and metastatic melanoma. |
| وصف الملف: | text; application/pdf |
| اللغة: | English |
| تدمد: | 2001-1326 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a063df7d49754c3c7df9d3dbf47b7402 http://doi.org/10.1002/ctm2.473 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a063df7d49754c3c7df9d3dbf47b7402 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20011326 |
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