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Clinical risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Mali

التفاصيل البيبلوغرافية
العنوان: Clinical risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Mali
المؤلفون: Gaoussou Berthé, Susan Orsega, D Goita, Antieme Combo Georges Togo, Bassirou Diarra, Nadie Coulibaly, Djeneba Dabitao, Bourahima Kone, Bindongo P.P. Dembele, Youssouf M. Kamia, T. Kanouté, Yacouba Toloba, Chad J. Achenbach, Michael Belson, Bocar Baya, Yeya dit Sadio Sarro, Dianguina Soumaré, Seydou Doumbia, Khadidia Ouattara, Sounkalo Dao, Maxwell O. Akanbi, Amadou Kone, Seydou Diabate, Mamoudou Maiga, Souleymane Diallo, Sophia Siddiqui, Moumine Sanogo, Robert L. Murphy
المصدر: International Journal of Infectious Diseases, Vol 81, Iss, Pp 149-155 (2019)
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Tuberculosis, Adolescent, 030106 microbiology, Drug resistance, Mali, Article, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Tuberculosis, Multidrug-Resistant, medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, Risk factor, Aged, Aged, 80 and over, GeneXpert MTB/RIF, Multi-Drug Resistant Tuberculosis, business.industry, Incidence (epidemiology), Multi-drug-resistant tuberculosis, General Medicine, Odds ratio, Middle Aged, medicine.disease, 3. Good health, Cross-Sectional Studies, Infectious Diseases, Risk factors, Sputum, Female, medicine.symptom, business
الوصف: Background: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF® has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. In this study, we aimed to determine the clinical factors associated with MDR-TB in Bamako, Mali. Methods: We performed a cross-sectional study of 214 patients with presumed MDR-TB admitted to University of Bamako Teaching Hospital, Point-G between 2007 and 2016. We calculated crude and adjusted odds ratios for MDR-TB disease diagnosis using SPSS. Results: We found that age ≤40 years (OR = 2.56. 95% CI: 1.44–4.55), two courses of prior TB treatment (OR = 3.25, 95% CI: 1.44–7.30), TB treatment failure (OR = 3.82, 95% CI 1.82–7.79), sputum microscopy with 3+ bacilli load (OR = 1.98, 95% CI: 1.13–3.48) and a history of contact with a TB patient (OR = 2.48, 95% CI: 1.11–5.50) were significantly associated with confirmation of MDR-TB disease. HIV was not a risk factor for MDR-TB (aOR = 0.88, 95% CI: 0.34–1.94). Conclusion: We identified several risk factors that could be used to identify MDR-TB suspects and prioritize them for laboratory confirmation. Prospective studies are needed to understand factors associated with TB incidence and clinical outcomes of TB treatment and disease. Keywords: Multi-Drug Resistant Tuberculosis, Risk factors, Mali
اللغة: English
تدمد: 1201-9712
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0669a4314e7b0d27b66914521ffe2fa
http://www.sciencedirect.com/science/article/pii/S1201971219300682
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....a0669a4314e7b0d27b66914521ffe2fa
قاعدة البيانات: OpenAIRE
الوصف
تدمد:12019712