The impact of implantable cardioverter-defibrillator implantation on health-related quality of life in the DANISH trial
| العنوان: | The impact of implantable cardioverter-defibrillator implantation on health-related quality of life in the DANISH trial |
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| المؤلفون: | Finn Gustafsson, Lars Videbæk, Hans Eiskjær, Lars Køber, Johan S Bundgaard, Flemming Hald Steffensen, Jensen G, Dan Eik Høfsten, Per Hildebrandt, Kenneth Egstrup, Jens Haarbo, Axel Brandes, Ulrik M. Mogensen, Jens Cosedis Nielsen, Eva Korup, Jens Jakob Thune, Jesper Hastrup Svendsen, Christian Torp-Pedersen, Thomas Melchior, Regitze Videbæk, Niels Eske Bruun, Ole Pedersen, Anna Margrethe Thøgersen, D T Aagaard, Susanne S. Pedersen, Steen Pehrson, Christian Hassager |
| المصدر: | Bundgaard, J S, Thune, J J, Nielsen, J C, Videbæk, R, Haarbo, J, Bruun, N E, Videbæk, L, Aagaard, D, Korup, E, Jensen, G, Hildebrandt, P, Steffensen, F H, Eiskjær, H, Brandes, A, Thøgersen, A M, Melchior, T M, Pedersen, O D, Gustafsson, F, Egstrup, K, Hassager, C, Svendsen, J H, Høfsten, D E, Torp-Pedersen, C, Pedersen, S S, Pehrson, S, Køber, L & Mogensen, U M 2019, ' The impact of implantable cardioverter-defibrillator implantation on health-related quality of life in the DANISH trial ', Europace, vol. 21, no. 6, pp. 900-908 . https://doi.org/10.1093/europace/euz018 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Quality of life, medicine.medical_specialty, Randomization, Denmark, medicine.medical_treatment, Heart failure, 030204 cardiovascular system & hematology, Implantable cardioverter-defibrillator, Danish, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Humans, In patient, 030212 general & internal medicine, Aged, Heart Failure, Health related quality of life, business.industry, Middle Aged, medicine.disease, Cardiovascular disease, language.human_language, Defibrillators, Implantable, Icd implantation, Quality of Life, language, Female, Cardiology and Cardiovascular Medicine, business |
| الوصف: | AIM: The Danish Study to Assess the Efficacy of Implantable Cardioverter-Defibrillators (ICD) in Patients with Non-ischaemic Systolic Heart Failure (HF) on Mortality (DANISH) found no overall effect on all-cause mortality. The effect of ICD implantation on health-related quality of life (HRQoL) remains to be established as previous trials have demonstrated conflicting results. We investigated the impact of ICD implantation on HRQoL in patients with non-ischaemic systolic HF, a prespecified secondary endpoint in DANISH.METHODS AND RESULTS: In DANISH, a total of 1116 patients with non-ischaemic systolic HF were randomly assigned (1:1) to ICD implantation or usual clinical care (control). Patients completed disease-specific HRQoL as assessed by Minnesota Living with Heart Failure Questionnaire (MLHFQ; 0-105, high indicating worse). Changes in HRQoL 8 months after randomization were assessed with a mixed-effects model. At randomization, MLHFQ was completed by 935 (84%) patients (n = 472 in the ICD group and n = 463 in the control group) and was reassessed in 274 (58%) and 292 (63%) patients, respectively after 8 months for the primary analysis. Patients in the ICD group vs. the control group had similar improvements in MLHFQ after 8 months [least square mean -7.0 vs. -4.2 (P = 0.13)]. A clinically relevant improvement (decrease ≥5) in the MLHFQ overall score at 8 months was observed in 151 patients in the ICD group and 148 patients in the control group [55% vs. 51%, respectively (P = 0.25)].CONCLUSION: Implantable cardioverter-defibrillator implantation in patients with non-ischaemic systolic HF did not significantly alter HRQoL compared with patients randomized to usual clinical care. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c0f860f673dc430d0e2149c58871ce https://portal.findresearcher.sdu.dk/da/publications/0bfb96a1-6376-43b7-b3e3-3ce9ba702293 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a0c0f860f673dc430d0e2149c58871ce |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |