Health-related quality of life after pancreatic resection for malignancy
| العنوان: | Health-related quality of life after pancreatic resection for malignancy |
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| المؤلفون: | Irene M. Lips, Jeroen Hagendoorn, H.D. Heerkens, H.C. van Santvoort, I. Q. Molenaar, Menno R. Vriens, I. H. M. Borel Rinkes, Gert J. Meijer, Dorine S.J. Tseng, M. van Vulpen |
| المصدر: | British Journal of Surgery, 103, 3, pp. 257-66 British Journal of Surgery, 103, 257-66 British Journal of Surgery, 103(3), 257. John Wiley and Sons Ltd |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Health Status, 030230 surgery, Malignancy, Preoperative care, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Pancreatectomy, Quality of life, Pancreatic cancer, Internal medicine, Surveys and Questionnaires, medicine, 80 and over, Journal Article, Humans, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, business.industry, Middle Aged, medicine.disease, humanities, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Pancreatic Neoplasms, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Randomized Controlled Trial, Quality of Life, Defecation, Female, Pancreas, business, Follow-Up Studies |
| الوصف: | Background Health-related quality of life (QoL) is of major importance in pancreatic cancer, owing to the limited life expectation. The aim of this prospective longitudinal study was to describe QoL in patients undergoing resection for pancreatic or periampullary malignancy. Methods QoL was measured on a scale of 0–100 in patients who underwent pancreatic resection for malignancy or premalignancy at the University Medical Centre Utrecht before resection, and 1, 3, 6 and 12 months after surgery. Measures consisted of the RAND-36, the European Organization for Research and Treatment of Cancer (EORTC) core questionnaire (QLQ-C30) and the EORTC pancreatic cancer-specific module (QLQ-PAN26). Results Between March 2012 and November 2013, 68 consecutive patients with a malignancy (59 patients) or premalignancy (9) were included. Physical role restriction, social and emotional domains showed a significant and clinically relevant deterioration directly after operation in 53 per cent (RAND-36, P < 0·001), 63 and 78 per cent (QLQ-C30 and RAND-36 respectively, P < 0·001) and 37 per cent (RAND-36, P < 0·001) of patients respectively. Most domains demonstrated recovery to preoperative values or better at 3 months, except for physical functioning. Emotional functioning at 3, 6 and 12 months was better than at baseline (P < 0·001). Symptom scores revealed a deterioration in vitality, pain (P = 0·002), fatigue (P < 0·001), appetite loss (P < 0·001), altered bowel habit (P = 0·001) and side-effects (P < 0·001) after 1 month. After 3 months, only side-effects were worse than preoperative values (P < 0·001). Conclusion QoL after pancreatic resection for malignant and premalignant tumours decreased considerably in the early postoperative phase. Full recovery of QoL took up to 6 months after the operation. |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 0007-1323 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16a0c005689d0e209670f654f18b4db https://dspace.library.uu.nl/handle/1874/344282 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a16a0c005689d0e209670f654f18b4db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00071323 |
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