Maprouneacin, a New Daphnane Diterpenoid with Potent Antihyperglycemic Activity from Maprounea africana
| العنوان: | Maprouneacin, a New Daphnane Diterpenoid with Potent Antihyperglycemic Activity from Maprounea africana |
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| المؤلفون: | J. L. Moswa, T. J. Carlson, Joann M. Krenisky, V. L. Hsu, Williamson Rt, Jian Luo, John R. Carney |
| المصدر: | Journal of Natural Products. 62:345-347 |
| بيانات النشر: | American Chemical Society (ACS), 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Blood Glucose, endocrine system diseases, Stereochemistry, Pharmaceutical Science, Pharmacognosy, Analytical Chemistry, Mice, chemistry.chemical_compound, Oral administration, In vivo, Drug Discovery, Animals, Hypoglycemic Agents, Pharmacology, biology, Traditional medicine, Chemistry, Body Weight, Organic Chemistry, Euphorbiaceae, Biological activity, Maprouneacin, Feeding Behavior, biology.organism_classification, Terpenoid, Diabetes Mellitus, Type 2, Complementary and alternative medicine, Molecular Medicine, Diterpenes, Diterpene |
| الوصف: | Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Compound 2 showed potent glucose-lowering properties when given by the oral route. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16e5ba29404ed360ca0812fd5571f5a https://doi.org/10.1021/np980356c |
| رقم الأكسشن: | edsair.doi.dedup.....a16e5ba29404ed360ca0812fd5571f5a |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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