Pre- and postnatal arsenic exposure and child development at 18 months of age: a cohort study in rural Bangladesh
العنوان: | Pre- and postnatal arsenic exposure and child development at 18 months of age: a cohort study in rural Bangladesh |
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المؤلفون: | Sally Grantham-McGregor, Sakila Yesmin, Britta Fängström, Barbro Nermell, Shams El Arifeen, Syed N. Huda, Jena D. Hamadani, Marcos Vera-Hernandez, Marie Vahter, Fahmida Tofail, Mahfuzar Rahman |
المصدر: | International Journal of Epidemiology. 39:1206-1216 |
بيانات النشر: | Oxford University Press (OUP), 2010. |
سنة النشر: | 2010 |
مصطلحات موضوعية: | Rural Population, Pediatrics, medicine.medical_specialty, Epidemiology, Health Status, chemistry.chemical_element, Bayley Scales of Infant Development, Arsenic, Cohort Studies, Child Development, Pregnancy, Water Supply, Arsenic Poisoning, Water Pollution, Chemical, medicine, Humans, Longitudinal Studies, Bangladesh, Arsenic toxicity, business.industry, Infant, Confounding Factors, Epidemiologic, General Medicine, Anthropometry, medicine.disease, Child development, Mental Health, Socioeconomic Factors, chemistry, Maternal Exposure, Prenatal Exposure Delayed Effects, Gestation, Female, business, Water Pollutants, Chemical, Cohort study |
الوصف: | Background Exposure to arsenic through drinking water has been associated with impaired cognitive function in school-aged children in cross-sectional studies; however, there are few longitudinal studies and little information on effects of exposure in early life when the brain is generally most vulnerable. Methods A longitudinal cohort study beginning in early pregnancy was conducted in rural Bangladesh, where arsenic concentrations in well water vary considerably. We assessed the effects of pre- and postnatal arsenic exposure on development of 2112 children at 18 months of age with Bayley Scales of Infant Development-II (mental and psychomotor development indices), Wolke's Behavior Rating Scale and maternal report of language. We related the measures of child development to arsenic concentrations in maternal urine in gestational weeks 9 and 30 and child's urinary arsenic at 18 months of age. Details of socio-economic background, home stimulation and anthropometric measurements of mothers and children were also available. Results Median maternal urinary arsenic concentration averaged over early and late gestation was 96 µg/l, whereas children's urine contained 35 µg/l of arsenic. There was no significant effect of any of the arsenic exposure measures on any of the child development measures after controlling for social and economic confounders, child's age and sex. Conclusion Contrary to expectations, we found no indications of adverse effects of pre- or postnatal arsenic exposure on child development at 18 months. It remains possible that duration of exposure is critical and that effects will become apparent later in childhood. |
تدمد: | 1464-3685 0300-5771 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17469c5a88e9610a740ebce87be2245 https://doi.org/10.1093/ije/dyp369 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....a17469c5a88e9610a740ebce87be2245 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14643685 03005771 |
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