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Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury

التفاصيل البيبلوغرافية
العنوان: Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury
المؤلفون: Toshiaki Suzuki, Akihiko Saitoh, Takeshi Yamada, David J. Nikolic-Paterson, Utako Kaneko, Toshio Yanagihara, Yohei Ikezumi, Masanori Hara, Hiroya Hasegawa
المصدر: Pediatric nephrology (Berlin, Germany). 30(6)
سنة النشر: 2014
مصطلحات موضوعية: Nephrology, Adult, Male, medicine.medical_specialty, Pathology, Time Factors, Adolescent, Biopsy, Population, Antigens, Differentiation, Myelomonocytic, Receptors, Cell Surface, Kidney, Dexamethasone, Young Adult, Fibrosis, Antigens, CD, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, education, Child, Cells, Cultured, Retrospective Studies, education.field_of_study, business.industry, CD68, Macrophages, Macrophage Activation, medicine.disease, Allografts, Immunohistochemistry, Kidney Transplantation, Transplantation, CTGF, medicine.anatomical_structure, Phenotype, Treatment Outcome, Pediatrics, Perinatology and Child Health, Female, Atrophy, business, CD163, Biomarkers, Immunosuppressive Agents
الوصف: Prevention of chronic kidney allograft injury (CAI) is a major goal in improving kidney allograft survival; however, the mechanisms of CAI are not clearly understood. The current study investigated whether alternatively activated M2-type macrophages are involved in the development of CAI. A retrospective study examined kidney allograft protocol biopsies (at 1 h and at years 1, 5, and 10—a total of 41 biopsies) obtained from 13 children undergoing transplantation between 1991 and 2008 who were diagnosed with CAI: interstitial fibrosis and tubular atrophy (IF/TA) not otherwise specified (IF/TA-NOS). Immunostaining identified a significant increase in interstitial fibrosis with accumulation of CD68 + CD163+ M2-type macrophages. CD163+ cells were frequently localized to areas of interstitial fibrosis exhibiting collagen I deposition and accumulation of α-smooth muscle actin (SMA) + myofibroblasts. There was a significant correlation between interstitial CD163+ cells and the parameters of interstitial fibrosis (p
تدمد: 1432-198X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18aae3d5fe1c2b2e903684be6cefa49
https://pubmed.ncbi.nlm.nih.gov/25487670
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....a18aae3d5fe1c2b2e903684be6cefa49
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1432198X