A unified multi‐activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS)
| العنوان: | A unified multi‐activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS) |
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| المؤلفون: | Andrew Hollander, Michael Weaver, Tawfik Giaddui, Curtis Miyamoto, B Micaily, Stephanie E. Weiss, Bin Wang, S Li |
| المصدر: | Medical Physics |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Coefficient of determination, Stereotactic body radiation therapy, Cell Survival, medicine.medical_treatment, Brachytherapy, HDR, Radiosurgery, 030218 nuclear medicine & medical imaging, SRS, 03 medical and health sciences, EQD2, 0302 clinical medicine, medicine, Range (statistics), Lung cancer, Cell survival, Survival analysis, Research Articles, Physics, SBRT, business.industry, General Medicine, medicine.disease, BIOLOGICAL PHYSICS AND RESPONSE PREDICTION, Radiobiological Outcome modeling, High-Dose Rate Brachytherapy, 030220 oncology & carcinogenesis, Dose Fractionation, Radiation, Nuclear medicine, business, Relative Biological Effectiveness, Research Article |
| الوصف: | PURPOSE Application of linear-quadratic (LQ) model to large fractional dose treatments is inconsistent with observed cell survival curves having a straight portion at high doses. We have proposed a unified multi-activation (UMA) model to fit cell survival curves over the entire dose range that allows us to calculate EQD2 for hypofractionated SBRT, SRT, SRS, and HDRB. METHODS A unified formula of cell survival S=n/eDDo+n-1 using only the extrapolation number of n and the dose slope of Do was derived. Coefficient of determination, R2 , relative residuals, r, and relative experimental errors, e, normalized to survival fraction at each dose point, were calculated to quantify the goodness in modeling of a survival curve. Analytical solutions for α and β, the coefficients respectively describe the linear and quadratic parts of the survival curve, as well as the α/β ratio for the LQ model and EQD2 at any fractional doses were derived for tumor cells undertaking any fractionated radiation therapy. RESULTS Our proposed model fits survival curves of in-vivo and in-vitro tumor cells with R2 > 0.97 and r |
| اللغة: | English |
| تدمد: | 2473-4209 0094-2405 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ad181a90de4cacba8a025b9822024f http://europepmc.org/articles/PMC8248130 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a1ad181a90de4cacba8a025b9822024f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24734209 00942405 |
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