Does dexmedetomidine have an antiarrhythmic effect on cardiac patients? A meta-analysis of randomized controlled trials
| العنوان: | Does dexmedetomidine have an antiarrhythmic effect on cardiac patients? A meta-analysis of randomized controlled trials |
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| المؤلفون: | Hongmei Zhou, Zhipeng Zhu, Yunjian Ni, Xiaoyan Ling, Caijun Zhang, Cheng Wu |
| المصدر: | PLoS ONE PLoS ONE, Vol 13, Iss 3, p e0193303 (2018) |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Databases, Factual, Cardiovascular Procedures, lcsh:Medicine, 030204 cardiovascular system & hematology, law.invention, Mathematical and Statistical Techniques, 0302 clinical medicine, Randomized controlled trial, Risk Factors, law, Tachycardia, Atrial Fibrillation, Medicine and Health Sciences, Odds Ratio, Medicine, 030212 general & internal medicine, Coronary Artery Bypass, lcsh:Science, Propofol, Randomized Controlled Trials as Topic, Cardiopulmonary Bypass, Coronary Artery Bypass Grafting, Multidisciplinary, Intensive care unit, Hospitals, Cardiac surgery, Intensive Care Units, Sedation, Meta-analysis, Anesthesia, Physical Sciences, medicine.symptom, Anti-Arrhythmia Agents, Arrhythmia, Statistics (Mathematics), Dexmedetomidine, Research Article, medicine.drug, medicine.medical_specialty, Cardiac Surgery, Heart Diseases, Cardiology, Surgical and Invasive Medical Procedures, Subgroup analysis, Research and Analysis Methods, 03 medical and health sciences, Humans, Statistical Methods, Pharmacology, business.industry, lcsh:R, Arrhythmias, Cardiac, Health Care, Health Care Facilities, lcsh:Q, business, Mathematics, Meta-Analysis |
| الوصف: | Background Cardiac surgery patients often experience several types of tachyarrhythmias after admission to the intensive care unit (ICU), which increases mortality and morbidity. Dexmedetomidine (DEX) is a popular medicine used for sedation in the ICU, and its other pharmacological characteristics are gradually being uncovered. Purpose To determine whether DEX has an antiarrhythmic effect after cardiac surgery. Methods The three primary databases MEDLINE, Embase (OVID SP) and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched, and all English-language and randomized control-designed clinical publications comparing DEX to control medicines for sedation after elective cardiac surgery were included. Two colleagues independently extracted the data and performed other quality assessments. A subgroup analysis was performed according to the different medicines used and whether cardiopulmonary bypass (CPB) was applied. All tachyarrhythmias that occurred in the atria and ventricles were analyzed. Results A total of 1295 patients in 9 studies met the selection criteria among 2587 studies that were screened. After quantitative synthesis, our results revealed that the DEX group was associated with a lower incidence of ventricular arrhythmia (VA, OR 0.24, 95% CI 0.09–0.64, I2 = 0%, P = 0.005) than the control group. Subgroup analysis did not reveal a significant difference between the DEX and propofol subgroups (OR 0.13, 95% CI 0.03–0.56, I2 = 0%, P = 0.007). Additionally, no difference in the incidence of atrial fibrillation (AF) was observed regardless of the different control medicines (OR 0.82, 95% CI 0.60–1.10, I2 = 25%, P = 0.19) or whether CPB was applied. Conclusions This meta-analysis revealed that DEX has an antiarrhythmic effect that decreases the incidence of VA compared to other drugs used for sedation following cardiac surgery. DEX may not have an effect on AF, but cautious interpretation should be exercised due to high heterogeneity. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c5507e32741a7dcc6c66ca58df25f0 https://doi.org/10.1371/journal.pone.0193303 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....a1c5507e32741a7dcc6c66ca58df25f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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